Mechanisms of biofunctionalization of photocorrosion-based semiconductor biosensors for quasi-continuous monitoring of pathogens in water environments
光腐蚀半导体生物传感器的生物功能化机制,用于准连续监测水环境中的病原体
基本信息
- 批准号:494057-2016
- 负责人:
- 金额:$ 16.3万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Strategic Projects - Group
- 财政年份:2017
- 资助国家:加拿大
- 起止时间:2017-01-01 至 2018-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Bacterial contamination of hot water plumbing and water processed in industrial cooling towers designed for air conditioning has led to frequent disease outbreaks in different countries, including Canada. To address the deficiencies of conventional methods of detecting pathogens in water, such as requirement to transport to a laboratory, long time-to-results (for culture), and expensive polymerase chain reaction, numerous biosensing platforms have been investigated, but without a satisfactory solution as of yet. We have been developing a novel class of quantum semiconductor photonic biosensing (QSPB) devices that employ standard GaAs-based semiconductor wafers, such as those used in the fabrication of ubiquitous light-emitting diode devices. This approach brings the potential of an automated, remote, and cost-attractive solution. The limit of detection (LOD) of Legionella pneumophila in water with our current QSPB biochips, combined with the chemotaxis effect and mechanical concentration of bacteria, has been estimated at 1 CFU/mL. This result would offer an adequate level of protection against pathogenic L. pneumophila, however, the requirement for highly efficient chemotaxis and mechanical concentration steps is challenging. Alternatively, the requirement to obtain such a low LOD could only be met by the availability of more sensitive QSPB devices. This proposal addresses the urgent need to undertake a systematic study of biofunctionalization science and technology that lags behind, especially when addressing the innovative QSPB technology, but which could lead to ultrasensitive detection of bacteria at an attractive cost. To achieve this goal, we collaborate with two Canadian companies, one specializing in implementing a nationwide program of monitoring L. pneumophila in water and the other in developing chicken antibodies as research and diagnostic tools.
热水管道和用于空调的工业冷却塔中处理的水的细菌污染导致包括加拿大在内的不同国家频繁爆发疾病。为了解决检测水中病原体的常规方法的缺陷,例如需要运输到实验室、长时间到结果(用于培养)和昂贵的聚合酶链式反应,已经研究了许多生物传感平台,但是到目前为止还没有令人满意的解决方案。我们一直在开发一类新型的量子半导体光子生物传感(QSPB)设备,采用标准的GaAs基半导体晶片,如那些用于制造无处不在的发光二极管器件。这种方法带来了一种自动化、远程和成本低廉的解决方案的潜力。结合细菌的趋化作用和机械浓度,我们目前的QSPB生物芯片对水中嗜肺军团菌的检测限(LOD)估计为1 CFU/mL。这一结果将提供足够的保护水平,对致病性L。然而,对于嗜肺菌来说,对高效趋化性和机械浓缩步骤的要求是具有挑战性的。或者,只有通过提供更灵敏的QSPB装置才能满足获得如此低LOD的要求。该提案解决了对生物功能化科学和技术进行系统研究的迫切需要,特别是在解决创新的QSPB技术时,但这可能导致以具有吸引力的成本对细菌进行超灵敏检测。为了实现这一目标,我们与两家加拿大公司合作,其中一家专门负责实施一项全国性的监测L。另一个在开发鸡抗体作为研究和诊断工具。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Dubowski, Jan其他文献
Dubowski, Jan的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Dubowski, Jan', 18)}}的其他基金
Digital photocorrosion of III-V semiconductors and transition metal dichalcogenides: fundamental and applied research of nanofabrication and molecular interactions at atomic level
III-V族半导体和过渡金属二硫化物的数字光腐蚀:原子级纳米加工和分子相互作用的基础和应用研究
- 批准号:
RGPIN-2020-05558 - 财政年份:2022
- 资助金额:
$ 16.3万 - 项目类别:
Discovery Grants Program - Individual
Digital photocorrosion of III-V semiconductors and transition metal dichalcogenides: fundamental and applied research of nanofabrication and molecular interactions at atomic level
III-V族半导体和过渡金属二硫化物的数字光腐蚀:原子级纳米加工和分子相互作用的基础和应用研究
- 批准号:
RGPIN-2020-05558 - 财政年份:2021
- 资助金额:
$ 16.3万 - 项目类别:
Discovery Grants Program - Individual
Digital photocorrosion of III-V semiconductors and transition metal dichalcogenides: fundamental and applied research of nanofabrication and molecular interactions at atomic level
III-V族半导体和过渡金属二硫化物的数字光腐蚀:原子级纳米加工和分子相互作用的基础和应用研究
- 批准号:
RGPIN-2020-05558 - 财政年份:2020
- 资助金额:
$ 16.3万 - 项目类别:
Discovery Grants Program - Individual
Photonic sensing platform based on photocorrosion of III-V semiconductor microstructures
基于III-V族半导体微结构光腐蚀的光子传感平台
- 批准号:
RGPIN-2015-04448 - 财政年份:2019
- 资助金额:
$ 16.3万 - 项目类别:
Discovery Grants Program - Individual
Photonic sensing platform based on photocorrosion of III-V semiconductor microstructures
基于III-V族半导体微结构光腐蚀的光子传感平台
- 批准号:
RGPIN-2015-04448 - 财政年份:2018
- 资助金额:
$ 16.3万 - 项目类别:
Discovery Grants Program - Individual
Development of a process for high-throughput fabrication of high-quality Fibre Bragg Grating cavities
开发高品质光纤布拉格光栅腔高通量制造工艺
- 批准号:
529456-2018 - 财政年份:2018
- 资助金额:
$ 16.3万 - 项目类别:
Engage Grants Program
Mechanisms of biofunctionalization of photocorrosion-based semiconductor biosensors for quasi-continuous**monitoring of pathogens in water environments
基于光腐蚀的半导体生物传感器的生物功能化机制,用于水环境中病原体的准连续**监测
- 批准号:
494057-2016 - 财政年份:2018
- 资助金额:
$ 16.3万 - 项目类别:
Strategic Projects - Group
Photonic sensing platform based on photocorrosion of III-V semiconductor microstructures
基于III-V族半导体微结构光腐蚀的光子传感平台
- 批准号:
RGPIN-2015-04448 - 财政年份:2017
- 资助金额:
$ 16.3万 - 项目类别:
Discovery Grants Program - Individual
Photonic sensing platform based on photocorrosion of III-V semiconductor microstructures
基于III-V族半导体微结构光腐蚀的光子传感平台
- 批准号:
RGPIN-2015-04448 - 财政年份:2016
- 资助金额:
$ 16.3万 - 项目类别:
Discovery Grants Program - Individual
相似海外基金
Development and biofunctionalization of novel endodontic cement of shape controlled complex oxides
形状控制复合氧化物新型牙髓水泥的开发和生物功能化
- 批准号:
20H03869 - 财政年份:2020
- 资助金额:
$ 16.3万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Mechanisms of biofunctionalization of photocorrosion-based semiconductor biosensors for quasi-continuous**monitoring of pathogens in water environments
基于光腐蚀的半导体生物传感器的生物功能化机制,用于水环境中病原体的准连续**监测
- 批准号:
494057-2016 - 财政年份:2018
- 资助金额:
$ 16.3万 - 项目类别:
Strategic Projects - Group
Mechanisms of biofunctionalization of photocorrosion-based semiconductor biosensors for quasi-continuousmonitoring of pathogens in water environments
用于水环境中病原体准连续监测的光腐蚀半导体生物传感器的生物功能化机制
- 批准号:
494057-2016 - 财政年份:2016
- 资助金额:
$ 16.3万 - 项目类别:
Strategic Projects - Group
Direct study of neurotransmitter/Action potential correlation with a CMOS integrated carbon nanotube sensors arrays
使用 CMOS 集成碳纳米管传感器阵列直接研究神经递质/动作电位相关性
- 批准号:
26790035 - 财政年份:2014
- 资助金额:
$ 16.3万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Biofunctionalization of metallic biomaterials by forming ceramic interface layers
通过形成陶瓷界面层实现金属生物材料的生物功能化
- 批准号:
25249094 - 财政年份:2013
- 资助金额:
$ 16.3万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Biofunctionalization of cancellous bone allografts for the therapy of critical size bone defects
松质骨同种异体移植物的生物功能化用于治疗临界尺寸骨缺损
- 批准号:
221326096 - 财政年份:2012
- 资助金额:
$ 16.3万 - 项目类别:
Research Grants
Syntheis and biofunctionalization of degradable ester-amide biomaterials for tissue engineering applications
用于组织工程应用的可降解酯酰胺生物材料的合成和生物功能化
- 批准号:
288130-2008 - 财政年份:2011
- 资助金额:
$ 16.3万 - 项目类别:
Discovery Grants Program - Individual
Synthesis and biofunctionalization of degradable poly(ester amide) biomaterials for tissue engineering
用于组织工程的可降解聚(酯酰胺)生物材料的合成及生物功能化
- 批准号:
378554-2009 - 财政年份:2011
- 资助金额:
$ 16.3万 - 项目类别:
Postgraduate Scholarships - Doctoral
Biofunctionalization of titanium oral implant by DLC coating and chemical modifications.
通过 DLC 涂层和化学修饰对钛口腔种植体进行生物功能化。
- 批准号:
23592895 - 财政年份:2011
- 资助金额:
$ 16.3万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Generic biofunctionalization of metals with electrodeposition of functional and biomolecules
通过功能分子和生物分子的电沉积进行金属的通用生物功能化
- 批准号:
22240059 - 财政年份:2010
- 资助金额:
$ 16.3万 - 项目类别:
Grant-in-Aid for Scientific Research (A)