Modelling disease causing hERG mutation in induced pluripotent stem cells (iPSC) using simultaneous mapping of voltage and calcium transients

使用电压和钙瞬变的同步映射对诱导多能干细胞 (iPSC) 中引起 hERG 突变的疾病进行建模

• 批准号: 349938
• 负责人: Sergeev Valentine
• 金额: $ 1.27万
• 依托单位: Simon Fraser University (Burnaby, B.C.)
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-12-01 至 2016-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=349938&lang=en
• 关键词: Arrhythmia; Biophysics; Cardiac Physiology; Children’S Health; Electrophysiology; Genome Editing; Human Ether-À-Go-Go-Related Gene (Herg); Ipsc; Long Qt Syndrome; Optical Mapping

Loss-of-function mutations in the human ether-a-go-go related gene (hERG) cause Long QT syndrome (LQT), predisposing the heart to highly lethal forms of cardiac arrhythmia. Recently, congenital arrhythmias, including LQT syndrome, have been implicated in

人类ether-a-go-go相关基因（hERG）的功能丧失突变导致长QT综合征（LQT），使心脏易患高度致命形式的心律失常。最近，先天性心律失常，包括LQT综合征，已被牵连，