Development of innovative optical technologies for quantitative blood perfusion imaging

开发用于定量血液灌注成像的创新光学技术

• 批准号: RTI-2016-00636
• 负责人: Dehaes, Mathieu
• 金额: $ 10.3万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=591507
• 关键词: Development; innovative; optical; technologies; quantitative

We are requesting a spectral-domain optical coherence tomography (SD-OCT) system for non-invasive high-speed blood perfusion measurement and high-resolution tissue architecture imaging. Requested tools and instruments will be integrated with existing equipment and consolidated in our common Facility for Biomedical Imaging at CHU Sainte-Justine in Montréal. The last two decades have seen great progress in biomedical imaging with the development of non-invasive optical instruments to measure specific parameters such as haemoglobin oxygen saturation, blood flow index and blood volume. Nevertheless, non-invasive measurement of microvascular blood perfusion remains challenging and is often limited by practical and technological issues. A relatively recent and extremely promising technique to measure blood perfusion and tissue architecture is SD-OCT. Recent advances in SD-OCT instrumentation provide the flexibility required for high-speed, high-resolution and unprecedented penetration for critical imaging applications. However, the existing OCT systems available at CHU Sainte-Justine, Hôpital Maisonneuve-Rosemont, École Polytechnique and Université de Montréal are clinical devices that do not allow high-speed data acquisition schemes needed for blood perfusion imaging. It is not possible to adapt or upgrade these systems, strictly implemented to limited data acquisition imaging rates, without the specific flexibility needed for research. Further progress and advance in biomedical imaging is thus limited at CHU Sainte-Justine and in Montréal due to this situation. The commitment of leading optical physicists from Hôpital Maisonneuve-Rosemont and École Polytechnique, as co-applicants and collaborators in the current application, is demonstrating the need and urgency of acquiring and developing the proposed SD-OCT platform. Funding matching support from the CHU Sainte-Justine Research center is additionally supporting the urgency in acquiring the proposed equipment. As biomedical imaging is in full emergence at CHU Sainte-Justine and in Montréal, this new platform will benefit research projects emerging from existing and new collaborations, and therefore the community will continue to grow. These research activities will likely generate a large number of HQP in biomedical imaging sciences, which will increase the quality of research and reputation of all team members’ laboratories.

我们正在申请一种用于无创高速血液灌注测量和高分辨率组织结构成像的谱域光学相干断层扫描（SD-OCT）系统。所需的工具和仪器将与现有设备集成，并整合到我们位于蒙特利尔CHU Sainte-Justine的生物医学成像共同设施中。在过去的二十年里，随着非侵入式光学仪器的发展，生物医学成像取得了巨大的进步，可以测量特定的参数，如血红蛋白氧饱和度，血流指数和血容量。然而，微血管血液灌注的非侵入性测量仍然具有挑战性，并且通常受到实际和技术问题的限制。SD-OCT是测量血液灌注和组织结构的一种相对较新且非常有前途的技术。SD-OCT仪器的最新进展为关键成像应用提供了高速、高分辨率和前所未有的穿透力所需的灵活性。然而，CHU Sainte-Justine、Hôpital Maisonneuve-Rosemont、École Polytechnique和Université de Montréal现有的OCT系统是临床设备，不允许血液灌注成像所需的高速数据采集方案。这是不可能的适应或升级这些系统，严格执行有限的数据采集成像速率，没有研究所需的具体灵活性。由于这种情况，生物医学成像的进一步发展和进步在CHU Sainte-Justine和蒙特利尔受到限制。来自Maisonneuve-Rosemont医院和École Polytechnique的领先光学物理学家作为当前应用的共同申请人和合作者的承诺证明了获得和开发拟议SD-OCT平台的必要性和紧迫性。来自CHU Sainte-Justine研究中心的资金匹配支持也支持了获得拟议设备的紧迫性。随着生物医学成像在CHU Sainte-Justine和蒙特利尔的全面出现，这个新平台将有利于现有和新合作中出现的研究项目，因此社区将继续增长。这些研究活动可能会产生大量的生物医学成像科学的HQP，这将提高研究质量和所有团队成员实验室的声誉。