Development of innovative optical technologies for quantitative blood perfusion imaging

我们需要一种用于非侵入性高速血液灌注测量和高分辨率组织结构成像的光谱域光学相干断层扫描（SD-OCT）系统。所要求的工具和仪器将与现有设备相结合，并整合到我们在蒙特兰萨塔尔圣贾斯汀大学的生物医学成像共同设施中。在过去的二十年里，随着非侵入性光学仪器的发展，生物医学成像取得了巨大的进步，这些仪器可以测量血红蛋白氧饱和度、血流量指数和血容量等特定参数。然而，微血管血流灌注的无创测量仍然具有挑战性，并且经常受到实际和技术问题的限制。SD-OCT是一种相对较新的、非常有前途的测量血液灌注和组织结构的技术。SD-OCT仪器的最新进展为关键成像应用提供了高速、高分辨率和前所未有的穿透所需的灵活性。然而，目前在CHU Sainte-Justine、Hôpital Maisonneuve-Rosemont、École Polytechnique和universitede montracimal的OCT系统是临床设备，不允许血液灌注成像所需的高速数据采集方案。不可能调整或升级这些系统，严格执行有限的数据采集成像速率，没有研究所需的特定灵活性。因此，由于这种情况，在圣贾斯汀大学和蒙特里萨伊塔尔大学生物医学成像方面的进一步进展和进步受到限制。来自Hôpital Maisonneuve-Rosemont和École Polytechnique的领先光学物理学家的承诺，作为当前应用程序的共同申请人和合作者，正在证明获取和开发拟议的SD-OCT平台的必要性和紧迫性。来自CHU Sainte-Justine研究中心的资金匹配支持也支持了购买拟议设备的紧迫性。随着生物医学成像在CHU Sainte-Justine和montracimal的全面兴起，这个新的平台将有利于现有和新的合作产生的研究项目，因此社区将继续发展。这些研究活动可能会在生物医学成像科学领域产生大量的HQP，这将提高研究质量和所有团队成员实验室的声誉。

We are requesting a spectral-domain optical coherence tomography (SD-OCT) system for non-invasive high-speed blood perfusion measurement and high-resolution tissue architecture imaging. Requested tools and instruments will be integrated with existing equipment and consolidated in our common Facility for Biomedical Imaging at CHU Sainte-Justine in Montréal. The last two decades have seen great progress in biomedical imaging with the development of non-invasive optical instruments to measure specific parameters such as haemoglobin oxygen saturation, blood flow index and blood volume. Nevertheless, non-invasive measurement of microvascular blood perfusion remains challenging and is often limited by practical and technological issues. A relatively recent and extremely promising technique to measure blood perfusion and tissue architecture is SD-OCT. Recent advances in SD-OCT instrumentation provide the flexibility required for high-speed, high-resolution and unprecedented penetration for critical imaging applications. However, the existing OCT systems available at CHU Sainte-Justine, Hôpital Maisonneuve-Rosemont, École Polytechnique and Université de Montréal are clinical devices that do not allow high-speed data acquisition schemes needed for blood perfusion imaging. It is not possible to adapt or upgrade these systems, strictly implemented to limited data acquisition imaging rates, without the specific flexibility needed for research. Further progress and advance in biomedical imaging is thus limited at CHU Sainte-Justine and in Montréal due to this situation. The commitment of leading optical physicists from Hôpital Maisonneuve-Rosemont and École Polytechnique, as co-applicants and collaborators in the current application, is demonstrating the need and urgency of acquiring and developing the proposed SD-OCT platform. Funding matching support from the CHU Sainte-Justine Research center is additionally supporting the urgency in acquiring the proposed equipment. As biomedical imaging is in full emergence at CHU Sainte-Justine and in Montréal, this new platform will benefit research projects emerging from existing and new collaborations, and therefore the community will continue to grow. These research activities will likely generate a large number of HQP in biomedical imaging sciences, which will increase the quality of research and reputation of all team members’ laboratories.