Ribozymes and DNAzymes-- ancient catalytic activities for modern biomedical and other utility

核酶和脱氧核糖核酸酶——现代生物医学和其他用途的古老催化活性

• 批准号: 105785-2012
• 负责人: Sen, Dipankar
• 金额: $ 5.17万
• 依托单位: Simon Fraser University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=593255
• 关键词: Ribozymes; DNAzymes; ancient; catalytic; activities

My laboratory conducts broad-ranging research on the fundamental properties of DNA and RNA, the shared genetic material of all living organisms. Particularly, we are interested in the catalytic properties of RNA/DNA. Defining the range of catalysis available to RNA and DNA enzymes (ribozymes and DNAzymes) is crucial for understanding how early bio-catalytic systems evolved on earth; how quite different biopolymers (DNA/RNA versus proteins) can meet specific catalytic challenges; and, for obtaining powerful new reagents that can be applied towards disease bio-sensing, therapeutics, as well as other, often unanticipated, uses.

我的实验室对DNA和RNA的基本性质进行了广泛的研究，DNA和RNA是所有生物体共有的遗传物质。特别是，我们对RNA/DNA的催化性质感兴趣。确定RNA和DNA酶（核酶和DNA酶）的催化范围对于理解早期生物催化系统如何在地球上进化至关重要;不同的生物聚合物（DNA/RNA与蛋白质）如何应对特定的催化挑战;以及获得强大的新试剂，可用于疾病生物传感，治疗，以及其他通常意想不到的用途。