Control of Reversible Growth Arrest and Survival by the C/EBP Family of Transcription Factors

C/EBP 转录因子家族对可逆生长停滞和存活的控制

• 批准号: 138265-2012
• 负责人: Bédard, André
• 金额: $ 1.89万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=593393
• 关键词: Control; Reversible; Growth; Arrest; Survival

Signaling pathways activated when cells exit the cell cycle and enter a state of reversible growth arrest, known as G0 or quiescence, remain poorly understood. In the last eighteen months, we have determined that low oxygen levels (hypoxia) provide the signal for the induction of growth-arrest specific (gas genes) in quiescent chicken embryo fibroblasts (CEF). Using the p20K lipocalin gene as a model of gas gene, we identified the CHOP-C/EBPß transcription factor as a novel hypoxia-responsive factor controlling the expression of gas genes in quiescent CEF.

当细胞退出细胞周期并进入可逆的生长停滞状态（称为G 0或静止）时激活的信号通路仍然知之甚少。在过去的18个月里，我们已经确定，低氧水平（缺氧）提供的信号诱导生长停滞特定（气体基因）在静止的鸡胚成纤维细胞（CEF）。以p20 K脂质运载蛋白基因作为gas基因的模型，我们鉴定了CHOP-C/EBP 3转录因子作为一种新的低氧应答因子，控制静止期CEF中gas基因的表达。