Aromatization-Based Methodology in the Synthesis of Designed and Naturally Occurring Pi Systems with Unusual Structures and Useful Properties

基于芳构化的方法合成具有不寻常结构和有用特性的设计和自然发生的 Pi 系统

• 批准号: 138554-2013
• 负责人: Bodwell, Graham
• 金额: $ 3.93万
• 依托单位: Memorial University of Newfoundland
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=593413
• 关键词: Aromatization; Based; Methodology; Synthesis; Designed

The overarching objective of the proposed research is to exploit methodology in the field of organic synthesis that has been developed in my group to design and synthesize polycyclic aromatic and heteroaromatic compounds with unusual structures and/or potentially useful properties. The synthesis of molecules with unusual structures is challenging because such systems are necessarily high in energy. The methodology used by my group to generate energetically unfavourable (and therefore very interesting and potentially useful) molecules owes its success to reactions that result in the formation of one or more "aromatic" rings. These energetically advantageous processes offset the disadvantages of forming distorted structures. Bending and battering molecules into shapes that deviate from ideal parameters in a systematic fashion provides an opportunity to learn about the relationships between changes in structure and changes in properties. This knowledge may then be used to design molecules with tailored properties, which may prove to be useful for a variety of applications, include sensors and optoelectronic devices.

所提出的研究的总体目标是利用我的小组开发的有机合成领域的方法来设计和合成具有不寻常结构和/或潜在有用性质的多环芳香族和杂芳香族化合物。具有不寻常结构的分子的合成是具有挑战性的，因为这样的系统必须具有高能量。我的小组用来产生能量上不利的（因此非常有趣和潜在有用的）分子的方法将其成功归功于导致形成一个或多个“芳族”环的反应。这些在能量上有利的过程抵消了形成扭曲结构的缺点。以系统的方式将分子弯曲和击打成偏离理想参数的形状提供了了解结构变化和性质变化之间关系的机会。然后，这些知识可以用于设计具有定制特性的分子，这可能被证明对各种应用有用，包括传感器和光电器件。