Characterization of genes isolated in a novel screen for mutants with altered mitotic lifespan in yeast

在酵母中有丝分裂寿命改变的突变体的新型筛选中分离的基因的表征

• 批准号: 239239-2012
• 负责人: Harkness, Troy
• 金额: $ 2.91万
• 依托单位: University of Saskatchewan
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=594240
• 关键词: Characterization; genes; isolated; novel; screen

INTRODUCTION: Why all living organisms age has been a most intriguing question for centuries. Using simple model systems, such as flies, worms, and yeast, single conserved genes have been identified that greatly impact cellular and whole animal lifespan. The health of single cell and multicellular organisms is a measure of cellular capacity to maintain lifespan. Every cell undergoes a series of divisions until a differentiated or senescent state is reached.

导言：几个世纪以来，为什么所有的生物都在年龄上一直是一个最耐人寻味的问题。使用简单的模型系统，如苍蝇、蠕虫和酵母，已经识别出对细胞和整个动物寿命有很大影响的单一保守基因。单细胞和多细胞生物体的健康状况是衡量细胞维持寿命的能力。每个细胞都经历了一系列的分裂，直到达到分化或衰老状态。