Optimizing metabolic functions in microbial production using synchronized populations

使用同步种群优化微生物生产中的代谢功能

• 批准号: 418393-2012
• 负责人: Sauvageau, Dominic
• 金额: $ 1.75万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=596335
• 关键词: Optimizing; metabolic; functions; microbial; production

It is now possible to use microbial processes to produce molecules in ways and quantities that were, until recently thought to be impossible. Novel strategies are constantly developed and improved to create value-added products in fields as varied as energy, pharmaceuticals and biomaterials. While many of these advances are promising in the laboratory, it is often a challenge to transfer them into economically viable processes. It is thus increasingly relevant to integrate the development of genetic tools and bioprocesses. Another important factor limiting the optimization of bio-production is the fact that cells in a population display a wide variety of different behaviors.

现在，使用微生物过程来生产分子的方式和数量是可能的，直到最近，人们还认为这是不可能的。不断开发和改进新的战略，以在能源、制药和生物材料等各种领域创造增值产品。虽然这些进展中的许多在实验室是有希望的，但将它们转化为经济上可行的过程往往是一个挑战。因此，将基因工具和生物过程的开发结合起来越来越重要。限制生物生产优化的另一个重要因素是一个群体中的细胞表现出各种各样的不同行为。