Phytoglycogen nanoparticles as a technology platform for engineered anti-infective agents

植物糖原纳米颗粒作为工程抗感染剂的技术平台

• 批准号: 494633-2016
• 负责人: Glasauer, Susan
• 金额: $ 0.9万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Engage Plus Grants Program
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=603208
• 关键词: Phytoglycogen; nanoparticles; technology; platform; engineered

PhytoSpherixTM nanoparticles are a nontoxic, biodegradable proprietary biomaterial generated by Mirexus Inc. (Guelph, ON) from Ontario-grown sweet corn. Each nanoparticle consists of a single molecule of highly-branched glucose homopolymer, providing a uniform surface physico-chemistry to which active ingredients can be conjugated. PhytoSpherixTM is especially suited for use in a wide range of applications for nutraceuticals, cosmetics, pharmaceuticals and biomedical applications. It can be modified by adding functional groups or various active pharmaceutical ingredients e.g. antibiotics. This last feature is pertinent: over the last decades few new antibiotics have entered the market, which is a globally-recognised concern.

PhytoSpherixTM纳米颗粒是一种无毒、可生物降解的专有生物材料，由Mirexus公司（Guelph， ON）从安大略省种植的甜玉米中生产。每个纳米颗粒由一个高支化的葡萄糖均聚物分子组成，提供了一个统一的表面物理化学，使有效成分可以偶联。PhytoSpherixTM特别适用于营养保健品、化妆品、制药和生物医学应用的广泛应用。它可以通过添加官能团或各种活性药物成分如抗生素来修饰。最后一个特征是相关的：在过去的几十年里，很少有新的抗生素进入市场，这是一个全球公认的问题。