Phytoglycogen nanoparticles as antibacterial drug delivery agents

植物糖原纳米颗粒作为抗菌药物递送剂

• 批准号: 485333-2015
• 负责人: Glasauer, Susan
• 金额: $ 1.81万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=584876
• 关键词: Phytoglycogen; nanoparticles; antibacterial; drug; delivery

PhytospherixTM nanoparticles are a proprietary biomaterial generated by Mirexus Inc. (Guelph, ON) from Ontario-grown sweet corn, and are natural, biodegradable, non-toxic and edible. These desirable properties can be used in a wide range of applications for nutraceuticals, cosmetics and pharmaceuticals, all of which must meet stringent regulatory requirements. The high density of active surface hydroxyl groups results in a unique combination of properties, such as very fast dissolution in water, low viscosity in aqueous solutions up to 25 % and shear thinning effects at higher concentrations. PhytospherixTM can be modified to carry antibiotics. The ability to tune its uniform surface chemistry can be exploited to ensure high efficacy as a carrier. This last feature is especially pertinent because few new antibiotics are anticipated to enter the market. This is a globally-recognised concern since pathogenic bacteria continue to develop resistance to most commercially available antibiotics. Furthermore, certain pathogenic bacteria can infect and survive as intracellular pathogens within host cells, including those cells of the immune system that are supposed to kill them. Once inside the cell, pathogens are more protected; higher antibiotics doses are needed to kill the internalised bacteria yet such high doses are often undesirable. Strong interest in novel antimicrobials has driven research in nano-enabled delivery systems. Such systems offer numerous benefits - reductions in dosage and systemic toxicity, increased bioavailability, targeted delivery, and controlled release. Mirexus has the in-house capability to produce high quality samples and to conjugate a wide variety of bioactive materials to PhytospherixTM but lacks the expertise and facilities to assess the antimicrobial properties of the proposed conjugates. The company seeks to address this by establishing a collaborative partnership with scientific expertise in the areas of microbial physiology, bacteria-nanoparticle material interactions and antimicrobials, and access to research facilities. Accessing these capabilities is vital to assess the commercialization potential of PhytospherixTM as a drug delivery agent.

PhytsperixTM纳米颗粒是由Mirexus Inc.(Guelph，ON)从安大略省种植的甜玉米中生产的一种专利生物材料，是天然的、可生物降解的、无毒的和可食用的。这些理想的特性可用于营养食品、化妆品和药品的广泛应用，所有这些都必须满足严格的监管要求。高密度的活性表面羟基导致了一系列独特的性能组合，如在水中非常快的溶解，在水溶液中的低粘度高达25%，以及在较高浓度下的剪切变稀效应。植酸菌TM可以被改造成携带抗生素。可以利用调节其均匀表面化学的能力来确保作为载体的高效率。最后这一点特别重要，因为预计几乎没有新的抗生素进入市场。这是一个 全球公认的关切，因为病原菌继续对大多数商业可获得的抗生素产生抗药性。此外，某些病原菌可以在宿主细胞内作为细胞内病原体感染和生存，包括那些应该杀死它们的免疫系统细胞。一旦进入细胞，病原体就得到了更好的保护；需要更高剂量的抗生素来杀死内化的细菌，但如此高的剂量往往是不受欢迎的。对新型抗菌剂的浓厚兴趣推动了纳米递送系统的研究。这种系统提供了许多好处--减少剂量和全身毒性，提高生物利用度，靶向递送和受控释放。 Mirexus有能力生产高质量的样品，并将各种生物活性材料连接到PhytsperixTM上，但缺乏评估拟议连接物的抗菌性能的专业知识和设施。该公司寻求通过在微生物生理学、细菌-纳米颗粒材料相互作用和抗菌剂以及使用研究设施等领域与科学专业知识建立合作伙伴关系来解决这一问题。获得这些能力对于评估作为药物递送剂的PhytsperixTM的商业化潜力至关重要。