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Optogenetic identification of the role of specific neurotransmitter receptor signaling in epileptogenesis

Optogenetic identification of the role of specific neurotransmitter receptor signaling in epileptogenesis
光遗传学鉴定特定神经递质受体信号传导在癫痫发生中的作用
批准号：
354360
负责人：
Avoli Massimo
金额：
$30.93万
依托单位：
Montreal Neurological Institute-Hospital
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2016
资助国家：
加拿大
项目状态：
已结题
起止时间：
2016-10-01 至 2021-10-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=354360&lang=en
关键词：
Entorhinal Cortex Epileptogenesis Gaba Type A Receptor Signaling Hippocampus Interneurons Mice Optogenetic Stimulation Pilocarpine Principal Cells Temporal Lobe Epilepsy

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英文摘要
Our goal is to control the changes in brain excitability that follow a precipitating event and lead to mesial temporal lobe epilepsy (MTLE); this process is known as epileptogenesis. To this end, we will employ an animal model in which spontaneous seizure
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