Estrogen and Memory Bias
雌激素和记忆偏差
基本信息
- 批准号:RGPIN-2016-06653
- 负责人:
- 金额:$ 2.04万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2016
- 资助国家:加拿大
- 起止时间:2016-01-01 至 2017-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
There is extensive evidence, albeit controversial, implicating estrogen and other ovarian hormones such as progesterone in the cognitive performance of women and other female mammals. There is little doubt that these hormones have a modulatory role in learning and cognition, however, the findings in this area may sometimes be contradictory in both the direction and magnitude of effect.
Rats learning to complete a maze can use one of several memory systems. Firstly, they may use several cues from the environment, or allocentric cues, to develop a cognitive map and use this approach to find the reward. This approach is referred to as a ‘place’ memory and is mediated predominantly by the hippocampus. Secondly, rats may use egocentric cues to learn where to go to find the reward. In this case, the rats would learn a series of habitual motor responses such as turn left then turn right. This approach is referred to as a ‘response’ memory and is mediated predominately by the dorsal striatum, also known as the caudate/putamen
We, along with others, have established that whether a female rat will use a place or response memory system is dependent upon the level of circulating estrogens. Moreover, our most recent findings suggest that memory system bias may be regulated, in part, by estrogen’s effects in the prefrontal cortex. These effects are rapid, suggesting that estrogen is acting through receptors other than the classical steroid/genomic receptors.
We have also established that there are three types of membrane receptors localized to the female rat prefrontal cortex. The more recently identified, GPER1, as well as the classical ERalpha and ERbeta, are also found at the membrane of neurons of the frontal cortex. These findings suggest exciting new directions we can take to explore the rapid effects of ovarian hormones on cognition.
The objectives of this proposal are to explore the influence of the female hormones estrogen and progesterone on neuroplasticity (changes in the structure of neuronal contacts), neurotranmission (changes in neurotransmitter release in response to environmental stimuli), and behavior (changes in paradigms testing multiple memory systems in female rats.
尽管存在争议,但有大量证据表明雌激素和其他卵巢激素(如孕酮)与女性和其他雌性哺乳动物的认知能力有关。毫无疑问,这些激素在学习和认知中具有调节作用,然而,这一领域的研究结果有时可能在方向和影响程度上相互矛盾。
学习走迷宫的老鼠可以使用几种记忆系统中的一种。首先,他们可能会使用来自环境的几个线索,或allocentric线索,开发一个认知地图,并使用这种方法来找到奖励。这种方法被称为“位置”记忆,主要由海马体介导。其次,老鼠可能会利用自我中心的线索来学习去哪里寻找奖励。在这种情况下,老鼠会学习一系列习惯性的运动反应,比如左转,然后右转。这种方法被称为“反应”记忆,主要由背侧纹状体介导,也称为尾状核/壳核
我们和其他人沿着已经确定,雌性大鼠是否会使用位置或反应记忆系统取决于循环雌激素的水平。此外,我们最近的研究结果表明,记忆系统的偏差可能受到调节,部分是由雌激素对前额叶皮层的影响。这些作用是迅速的,表明雌激素通过受体而不是经典的类固醇/基因组受体起作用。
我们还建立了有三种类型的膜受体定位于雌性大鼠前额叶皮层。最近发现的GPER 1以及经典的ER α和ER β也在额叶皮层神经元的膜上发现。这些发现表明,我们可以采取令人兴奋的新方向来探索卵巢激素对认知的快速影响。
本提案的目的是探索雌性激素雌激素和孕激素对神经可塑性(神经元接触结构的变化)、神经传递(神经递质释放对环境刺激的反应变化)和行为(雌性大鼠多种记忆系统测试范式的变化)的影响。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Brake, Wayne其他文献
Brake, Wayne的其他文献
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{{ truncateString('Brake, Wayne', 18)}}的其他基金
Ovarian Hormones and Cognition
卵巢激素与认知
- 批准号:
RGPIN-2022-04690 - 财政年份:2022
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Estrogen and Memory Bias
雌激素和记忆偏差
- 批准号:
RGPIN-2016-06653 - 财政年份:2021
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Estrogen and Memory Bias
雌激素和记忆偏差
- 批准号:
RGPIN-2016-06653 - 财政年份:2020
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Estrogen and Memory Bias
雌激素和记忆偏差
- 批准号:
RGPIN-2016-06653 - 财政年份:2019
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Estrogen and Memory Bias
雌激素和记忆偏差
- 批准号:
RGPIN-2016-06653 - 财政年份:2018
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Estrogen and Memory Bias
雌激素和记忆偏差
- 批准号:
RGPIN-2016-06653 - 财政年份:2017
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Estrogen and cognitive strategy
雌激素和认知策略
- 批准号:
311886-2010 - 财政年份:2014
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Estrogen and cognitive strategy
雌激素和认知策略
- 批准号:
311886-2010 - 财政年份:2013
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Estrogen and cognitive strategy
雌激素和认知策略
- 批准号:
311886-2010 - 财政年份:2012
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Estrogen and cognitive strategy
雌激素和认知策略
- 批准号:
311886-2010 - 财政年份:2011
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
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