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Notch as master regulator of breast cancer subtype and intratumoral heterogeneity

Notch as master regulator of breast cancer subtype and intratumoral heterogeneity
Notch作为乳腺癌亚型和瘤内异质性的主要调节因子
批准号：
364267
负责人：
Egan Sean E
金额：
$0.0万
依托单位：
Hospital for Sick Children (Toronto)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2017
资助国家：
加拿大
项目状态：
已结题
起止时间：
2017-02-01 至 2020-02-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=364267&lang=en
关键词：
Asymmetry Breast Cancer Cell Fate Heterogeneity Human Culture Systems Mouse Models Notch P53 Polycomb Complexes

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英文摘要
Estrogen receptor-negative breast tumors include cells with a mixture of differentiated states. This issue creates a challenge with respect to development of effective treatment. Indeed, cellular heterogeneity within these cancers can lead to the genera
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