A combined nanotechnology and surgical strategy to treating liver cancer

肝癌目前很难治疗，成功治疗这种癌症所需的化疗药物量很高。在这个项目中，我们计划将肝脏从宿主体内取出，并在肝脏中注入含有抗癌药物5-氟尿嘧啶的纳米颗粒，该纳米颗粒可以靶向巨噬细胞肿瘤浸润细胞。这些细胞支持肿瘤系统的存活。这种注入肝脏的纳米容器将被重新植入动物体内。纳米颗粒在2-3周后分解，释放药物，杀死浸润细胞的巨噬细胞，从而摧毁肿瘤。这应该会提高动物的存活率。我们的商业伙伴专门开发针对肝癌细胞的药物和蛋白质。将治疗生物制药的专业知识与研究人员在纳米技术、肝脏、外科和物理方面的独特专业知识从学术方面结合起来，将产生治疗肝癌的新策略。

Liver cancer is currently difficult to treat and the required amount of chemotherapeutics to successfully treat this cancer ishigh. In this project, we plan to remove the liver from the host and infuse the liver with a nanoparticle that contains thecancer-fighting drug 5-fluorouracil and that can target macrophage tumor infiltrating cells. These cells support the survival ofthe tumor system. This nanocontainer infused liver will be re-implanted into the animal. The nanoparticle breaks apart after2-3 weeks to release the drug and kill the macrophage tumor infiltrating cells and therefore, destroying the tumor. Thisshould lead to an increase in the survival of the animal. Our commercial partner specializes in developing drugs and proteinsthat can target liver cancer cells. Combining the expertise of the Therapure Biopharma with the unique expertise ofresearchers in nanotechnology, liver, surgery, and physics from the academic side will lead to new strategies to treat livercancer.