A combined nanotechnology and surgical strategy to treating liver cancer

肝癌目前难以治疗，并且成功治疗这种癌症所需的化疗药物的量很高。在这个项目中，我们计划从宿主体内取出肝脏，并将含有抗癌药物5-氟尿嘧啶的纳米颗粒注入肝脏，该纳米颗粒可以靶向巨噬细胞肿瘤浸润细胞。这些细胞支持肿瘤系统的存活。将该纳米容器输注的肝脏重新植入动物体内。纳米颗粒在2 -3周后分解以释放药物并杀死巨噬细胞肿瘤浸润细胞，从而破坏肿瘤。这将导致动物存活率的提高。我们的商业合作伙伴专门开发针对肝癌细胞的药物和蛋白质。将Therapure Bioburma的专业知识与来自学术方面的纳米技术，肝脏，外科手术和物理学研究人员的独特专业知识相结合，将导致治疗肝癌的新策略。

Liver cancer is currently difficult to treat and the required amount of chemotherapeutics to successfully treat this cancer ishigh. In this project, we plan to remove the liver from the host and infuse the liver with a nanoparticle that contains thecancer-fighting drug 5-fluorouracil and that can target macrophage tumor infiltrating cells. These cells support the survival ofthe tumor system. This nanocontainer infused liver will be re-implanted into the animal. The nanoparticle breaks apart after2-3 weeks to release the drug and kill the macrophage tumor infiltrating cells and therefore, destroying the tumor. Thisshould lead to an increase in the survival of the animal. Our commercial partner specializes in developing drugs and proteinsthat can target liver cancer cells. Combining the expertise of the Therapure Biopharma with the unique expertise ofresearchers in nanotechnology, liver, surgery, and physics from the academic side will lead to new strategies to treat livercancer.