Characterization of genetic enhancers of ksr-1 lethality in C. elegans

线虫 ksr-1 致死率遗传增强子的表征

• 批准号: 341579-2013
• 负责人: Rocheleau, Christian
• 金额: $ 2.19万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629131
• 关键词: Characterization; genetic; enhancers; ksr; lethality

The nematode Caenorhabditis elegans is a very powerful genetic model organism for the identification of genes and regulatory systems that mediate the complexities of organism development. Cell proliferation, cell fate specification and morphogenesis must be properly coordinated such that a single cell can develop into a multicellular organism with many tissue types. Cell signaling is essential for cells to communicate and coordinate their actions during development. A handful signaling pathways are highly conserved across metazoan species from worm to man that are used repeatedly during development. Our lab is using C. elegans to understand how one such pathway is differentially regulated in different cell types and at different stages of development. Such studies will provides us with new paradigms by which we can understand how signaling during development is regulated. Furthermore, they provide new potential drug targets for the development of pharmaceuticals.

线虫秀丽隐杆线虫是一种非常有力的遗传模型生物体，用于鉴定介导生物体发育复杂性的基因和调节系统。细胞增殖，细胞命运规范和形态发生必须适当协调，以使单个细胞可以发展为具有许多组织类型的多细胞生物。细胞信号对于细胞在发育过程中进行交流和协调其作用至关重要。从蠕虫到人的蠕虫，少数信号通路是高度保守的，在发育过程中反复使用。我们的实验室正在使用秀丽隐杆线虫来了解一种这样的途径在不同的细胞类型和不同开发阶段如何差异地调节。这样的研究将为我们提供新的范式，通过这些范式我们可以了解开发过程中的信号传导如何受到调节。此外，它们为药物开发提供了新的潜在药物靶标。