Regulation of translation initiation under stress conditions

应激条件下翻译起始的调节

• 批准号: RGPIN-2016-03938
• 负责人: Hirasawa, Kensuke(Ken)
• 金额: $ 2.26万
• 依托单位: Memorial University of Newfoundland
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629189
• 关键词: Regulation; translation; initiation; under; stress

Two major steps of gene expression are transcription and translation. In the last 20 years, gene expression research has mainly focused on transcriptional regulation as microarray analysis became established. However, recent studies using genomic and proteomic profiling have revealed that changes in mRNA levels only partially correspond to those in protein levels. This suggests that translational regulation also plays critical roles in the regulation of gene expression. Translational regulation may be particularly important when cells respond to a rapid environmental change caused by cellular stresses.

基因表达的两个主要步骤是转录和翻译。在过去的20年里，基因表达研究主要集中在转录调控的微阵列分析成为建立。然而，最近使用基因组和蛋白质组分析的研究表明，mRNA水平的变化仅部分对应于蛋白质水平的变化。这表明翻译调控在基因表达调控中也起着关键作用。当细胞对由细胞应激引起的快速环境变化做出反应时，翻译调节可能特别重要。