SRF-independent roles of Myocardin in differentiation of vascular smooth muscle cells

心肌素在血管平滑肌细胞分化中的 SRF 独立作用

• 批准号: RGPIN-2017-04889
• 负责人: Zheng, XiLong
• 金额: $ 1.89万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629311
• 关键词: SRF; independent; roles; Myocardin; differentiation

It is critical to understand the molecular mechanisms underlying the regulation of vascular functions. The medial layers of blood vessels are composed of smooth muscle cells (SMCs), which perform the contractile functions of blood vessels, arteries in particular. The differentiation of vascular SMCs and their associated contractile functions are under the control of myocardin, a master transcriptional co-factor that activates the transcription of genes that encode smooth muscle-specific contractile proteins. During aging and the onset of age-related vascular pathologies, vascular SMCs undergo phenotypic conversion, which is associated with loss of the differentiated/contractile phenotype, and concomitant acquisition of a synthetic phenotype, including enhanced proliferation,

了解血管功能调节的分子机制是至关重要的。血管的中层由平滑肌细胞（smooth muscle cell，SMCs）组成，其执行血管特别是动脉的收缩功能。血管平滑肌细胞的分化及其相关的收缩功能是在肌心蛋白的控制下，肌心蛋白是激活编码平滑肌特异性收缩蛋白的基因转录的主转录辅因子。在衰老和年龄相关的血管病变的发作期间，血管SMC经历表型转换，其与分化/收缩表型的丧失以及伴随的合成表型的获得（包括增强的增殖、