Identification of functional links between redox homeostasis and immunity

氧化还原稳态与免疫之间功能联系的识别

• 批准号: 311589-2013
• 负责人: Scorza, Tatiana
• 金额: $ 2.62万
• 依托单位: Université du Québec à Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629318
• 关键词: Identification; functional; links; between; redox

Identification of functional links between redox homeostasis and immunityI study the biology of macrophages, which are cells contributing to immune defenses, tissue repair, elimination of dead cells and erythropoiesis. Erythropoiesis is the process by which new red blood cells (RBCs) are generated to replace senescent cells and ensure transport of oxygen to every tissue and elimination of carbon dioxide. Macrophages are essential for erythropoiesis as they nurse non-differentiated RBCs and guide their growth, survival and maturation in response to erythropoietin. In conditions of RBC loss (bleeding and others), the body increases the levels of erythropoietin to stimulate erythropoiesis, and the behavior of macrophages are changed to allow enhanced production of RBCs. The factors leading to these changes in macrophages remain unknown, and it is important to identify them and understand how they affect their biology, in order to develop strategies to stimulate the regeneration of RBCs and to cope with various conditions characterized by insufficient RBC numbers. To succeed in this research we will establish new experimental models to induce the production of RBCs in the laboratory and investigate how macrophages ensure their nursing roles in erythropoiesis. We will also investigate the impact for high levels of erythropoietin on the interactions of macrophages with forming RBCs, which are sustained by their secretion of growth factors and their expression of proteins to provide tight cell to cell contact.

氧化还原稳态和免疫之间的功能联系的鉴定我研究巨噬细胞的生物学，巨噬细胞是有助于免疫防御，组织修复，消除死细胞和红细胞生成的细胞。红细胞生成是生成新的红细胞（RBC）以取代衰老细胞并确保将氧气输送到每个组织并消除二氧化碳的过程。巨噬细胞对于红细胞生成是必不可少的，因为它们护理未分化的RBC并指导它们响应于红细胞生成素的生长、存活和成熟。在红细胞损失（出血和其他）的条件下，身体增加促红细胞生成素的水平以刺激红细胞生成，并且巨噬细胞的行为发生变化以允许增加红细胞的产生。导致巨噬细胞中这些变化的因素仍然未知，重要的是要识别它们并了解它们如何影响其生物学，以便制定刺激RBC再生的策略并科普以RBC数量不足为特征的各种疾病。为了在这项研究中取得成功，我们将建立新的实验模型，在实验室中诱导红细胞的产生，并研究巨噬细胞如何确保其在红细胞生成中的护理作用。我们还将研究高水平的促红细胞生成素对巨噬细胞与形成红细胞的相互作用的影响，所述红细胞通过其生长因子的分泌和其蛋白质的表达来维持，以提供紧密的细胞与细胞接触。