Investigating the relationship between posttranslational modifications and neuronal activity in controling AMPA receptor expression

研究翻译后修饰与控制 AMPA 受体表达的神经元活动之间的关系

• 批准号: RGPIN-2017-05392
• 负责人: Lussier, Marc
• 金额: $ 1.89万
• 依托单位: Université du Québec à Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630062
• 关键词: Investigating; relationship; between; posttranslational; modifications

It is evident that the mammalian brain plays a central role in various tasks such as memory formation and learning. In order to do so, the brain relies on its ability to preserve the function of specific neuronal connections called synapses. Given that synapses are the functional units of the brain where specific neurotransmitter receptors are localized, understanding the specific mechanisms that accurately and precisely regulate their function is of prime importance.

显然，哺乳动物的大脑在记忆形成和学习等各种任务中发挥着核心作用。为了做到这一点，大脑依靠其保留称为突触的特定神经元连接功能的能力。鉴于突触是大脑中特定神经递质受体定位的功能单位，了解准确且精确地调节其功能的特定机制至关重要。