Mechanisms regulating transendothelial transport of endocrine hormones and their significance

哺乳动物在适应环境方面面临的挑战必须得到严格控制，以确保最佳的生理功能。为了实现这一点，哺乳动物已经进化成具有各种管家系统(主要由激素调节)，以维持健康的身体功能。其中许多荷尔蒙在血液中流动，这就是它们到达身体不同部位的方式。为了对靶细胞或身体部位产生影响，荷尔蒙必须从哺乳动物的循环中出来，进入组织。我们认为，了解这种现象是如何发生的，是哺乳动物生理学中一个研究不足的领域。在这里，我们将研究荷尔蒙如何穿过排列在所有血管内的细胞屏障，尤其是我们关注相邻细胞之间的运动。

The challenges faced by mammals in adapting to their environment must be tightly controlled in order to ensure the best physiological function. To achieve this, mammals have evolved to have various housekeeping systems (mostly mediated by hormones) that maintain a healthy body function. Many of these hormones travel in the bloodstream and this is how they reach to various parts of the body. To have an effect on the target cell or body part, a hormone must exit from the circulation of the mammal and enter that tissue. We believe that understanding how this happens is an understudied area of mammalian physiology. Here we will study how a hormone moves across the barrier of cells lining all blood vessels and in particular we focus on movement between adjacent cells.