Adaptive Responses to Stress and Mortality Risk with Emphasis on Aging Rates

对压力和死亡风险的适应性反应，重点关注老龄化率

• 批准号: RGPIN-2015-05693
• 负责人: Rollo, Christopher
• 金额: $ 1.75万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630883
• 关键词: Adaptive; Responses; Stress; Mortality; Risk

My laboratory seeks to understand why animals age at such different rates, what processes are associated with aging and how we can manipulate aging rates. Studying aging requires animals that have short lives. We developed crickets as a model of aging because young crickets resemble adults and eat similar food. Genes that impact aging in crickets are VERY similar in all animals. Crickets live about 120 days whereas the oldest human so far lived 122 years. We have extended the cricket lifespan to 257 days. We designed a multi-ingredient dietary formulation that extends longevity, reduces cancer and slows deterioration in the brains and bodies of aging mice. This treatment was designed to help five things associated with aging. These include 1) neutralizing the toxic byproducts generated by the tiny furnaces (called mitochondria) that make energy in all animal cells. These byproducts essentially cause “biological rusting;” 2) making the furnaces work better so they produce less toxins but still make enough energy to prevent the declines otherwise accompanying aging; 3) reducing excess activity of the immune system that can cause damage; 4) maintaining the actions of insulin (related to energy supply and diabetes); and 5) maintaining youthful cell membranes that transmit neuronal firing and transport food, O2, CO2 and waste in all animal cells. Cricket studies will help us derive an improved intervention that can serve as a research tool.

我的实验室试图了解为什么动物以如此不同的速度衰老，什么过程与衰老有关，以及我们如何操纵衰老速度。研究衰老需要寿命短的动物。我们将蟋蟀作为衰老的模型，因为年轻的蟋蟀与成年蟋蟀相似，吃类似的食物。影响蟋蟀衰老的基因在所有动物中都非常相似。蟋蟀的寿命约为120天，而迄今为止最古老的人类寿命为122岁。我们将蟋蟀的寿命延长到257天。我们设计了一种多成分的饮食配方，可以延长寿命，减少癌症，减缓衰老小鼠大脑和身体的退化。这种治疗旨在帮助与衰老有关的五件事。这些措施包括：1）中和所有动物细胞中产生能量的微小熔炉（称为线粒体）产生的有毒副产品。这些副产品基本上会导致“生物生锈”; 2）使熔炉更好地工作，使它们产生更少的毒素，但仍然产生足够的能量来防止衰退，否则伴随着衰老; 3）减少可能导致损害的免疫系统的过度活动; 4）维持胰岛素的作用。（与能量供应和糖尿病有关）;和5）维持年轻的细胞膜，其在所有动物细胞中传递神经元放电和运输食物、O2、CO2和废物。板球研究将帮助我们获得一种改进的干预措施，可以作为一种研究工具。