Transport and Metabolism in Fish

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In a country with the longest coastline in the world, with 1/7 of the world’s freshwater, & an economy where fish and fisheries contribute over $17B annually (sportfishing ~ $10B, commercial fishing ~ $6B, aquaculture ~ $1B), the importance of understanding the basic physiology of fish & protecting the health of natural waters cannot be overstated. The present application opens new frontiers in a long term research program aimed at understanding the mechanisms involved in the transport & metabolism of nutrients, wastes, ions, acid-base equivalents, & respiratory gases in fish, & how these processes are modified by environmental conditions & phylogeny. This basic research program underpins a parallel applied program in aquatic toxicology, aquaculture, & environmental management. Mechanisms are analyzed at molecular, cellular, organ system, whole animal, & behavioral levels simultaneously. A comparative approach is used with respect to species (trout, killifish, sharks, hagfish, zebrafish etc.) & stressors (ammonia, O