Transport and Metabolism in Fish

在一个拥有世界上最长的海岸线、拥有世界七分之一淡水的国家，以及一个渔业和渔业每年贡献超过170亿美元(体育渔业~100亿美元，商业渔业~60亿美元，水产养殖~10亿美元)的经济体，了解鱼类的基本生理和保护自然水域健康的重要性怎么强调都不为过。本申请开辟了一个长期研究计划的新领域，该计划旨在了解鱼类中营养物质、废物、离子、酸碱当量和呼吸气体的运输和代谢机制，以及这些过程是如何被环境条件和系统发育所改变的。这一基础研究项目是水生毒理学、水产养殖和环境管理的并行应用项目的基础。同时从分子、细胞、器官系统、整个动物和行为水平分析了发病机制。对物种(鲑鱼、剑鱼、鲨鱼、八角鳗、斑马鱼等)和应激源(氨、氧)采用比较的方法。

In a country with the longest coastline in the world, with 1/7 of the world’s freshwater, & an economy where fish and fisheries contribute over $17B annually (sportfishing ~ $10B, commercial fishing ~ $6B, aquaculture ~ $1B), the importance of understanding the basic physiology of fish & protecting the health of natural waters cannot be overstated. The present application opens new frontiers in a long term research program aimed at understanding the mechanisms involved in the transport & metabolism of nutrients, wastes, ions, acid-base equivalents, & respiratory gases in fish, & how these processes are modified by environmental conditions & phylogeny. This basic research program underpins a parallel applied program in aquatic toxicology, aquaculture, & environmental management. Mechanisms are analyzed at molecular, cellular, organ system, whole animal, & behavioral levels simultaneously. A comparative approach is used with respect to species (trout, killifish, sharks, hagfish, zebrafish etc.) & stressors (ammonia, O