Transport and Metabolism in Fish

在一个拥有世界上最长的海岸线、拥有世界1/7淡水的国家，过程受到环境条件的影响：(Ii)“渗透呼吸折衷”，即离子/水与鳃的O2交换之间的功能权衡；(Iii)摄食生理；(Iv)溶解有机物(DOM，一种丰富的、普遍存在但鲜为人知的天然水成分)在调节鳃生理方面的重要性。具体项目集中在NH3作为一种呼吸气体在呼吸调节中的功能，它与O2生理学的相互作用被探索，包括酸碱信号的重要性，与食物摄取相关的运输途径的上调，O2喂养的成本及其与缺氧和运动表现的相互作用被量化。通过与化学家的合作，研究了不同类型DOM分子的物理化学及其对鳃离子调节功能的支持作用之间的关系。特别强调了DOM分子中金属结合部分的作用(S)，与DOM暴露相关的鳃结构变化，以及鱼类对自然生态系统的适应。总体而言，该项目将培训3名博士后研究员、5名博士和15名本科生在综合鱼类生理学的创新方面。

In a country with the longest coastline in the world, with 1/7 of the world's freshwater, processes are modified by environmental conditions (ii) the “osmorespiratory compromise” which is the functional tradeoff between ion/water vs O2 exchange at the gills; (iii) the physiology of feeding; (iv) the importance of dissolved organic matter (DOM, an abundant, ubiquitous but poorly understood component of all natural waters) in regulating gill physiology. Particular projects focus on the functions of NH3 as a respiratory gas in the regulation of breathing, its interactions with O2 ysiology are explored, including the importance of acid-base signals, the upregulation of transport pathways associated with food ingestion, O2 costs of feeding & their interactions with hypoxia & exercise performance are quantified. Through collaboration with a chemist, the relationships between the physical chemistry of different types of DOM molecules & their supportive actions on gill ionoregulatory function are examined. Particular emphasis is placed on the role(s) of metal-binding moieties in DOM molecules, on structural changes in gills associated with DOM exposures, & on the adaptation of fish to native DOMs. Overall, this program will train 3 postdoctoral fellows, 5 PhDs, & 15 undergrads in innovative aspects of integrative fish physiology.