Transport and Metabolism in Fish

鱼类的运输和代谢

• 批准号: RGPIN-2017-03843
• 负责人: Wood, Christopher
• 金额: $ 8.01万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=692962
• 关键词: Transport; Metabolism; Fish

In a country with the longest coastline in the world, with 1/7 of the world's freshwater, processes are modified by environmental conditions (ii) the “osmorespiratory compromise” which is the functional tradeoff between ion/water vs O2 exchange at the gills; (iii) the physiology of feeding; (iv) the importance of dissolved organic matter (DOM, an abundant, ubiquitous but poorly understood component of all natural waters) in regulating gill physiology. Particular projects focus on the functions of NH3 as a respiratory gas in the regulation of breathing, its interactions with O2 ysiology are explored, including the importance of acid-base signals, the upregulation of transport pathways associated with food ingestion, O2 costs of feeding & their interactions with hypoxia & exercise performance are quantified. Through collaboration with a chemist, the relationships between the physical chemistry of different types of DOM molecules & their supportive actions on gill ionoregulatory function are examined. Particular emphasis is placed on the role(s) of metal-binding moieties in DOM molecules, on structural changes in gills associated with DOM exposures, & on the adaptation of fish to native DOMs. Overall, this program will train 3 postdoctoral fellows, 5 PhDs, & 15 undergrads in innovative aspects of integrative fish physiology.

在一个拥有世界上最长海岸线的国家，拥有世界上1/7的淡水，环境条件改变了过程 (ii)“呼吸平衡”是鳃处离子/水与O2交换之间的功能权衡;（iii）摄食生理学;（iv）溶解有机物（DOM，所有天然沃茨中丰富、普遍但知之甚少的组分）在调节鳃生理学中的重要性。特别的项目集中在NH3作为呼吸气体在呼吸调节中的功能，探索其与O2生理学的相互作用，包括酸碱信号的重要性，与食物摄入相关的运输途径的上调，喂养的O2成本及其与缺氧和运动表现的相互作用被量化。 通过与化学家的合作，研究了不同类型DOM分子的物理化学之间的关系及其对鳃离子调节功能的支持作用。特别强调的是放置在DOM分子中的金属结合部分的作用（S），与DOM曝光相关的鳃的结构变化，以及鱼类对本地DOM的适应。 总的来说，该计划将培养3名博士后研究员，5名博士和15名本科生在综合鱼类生理学的创新方面。