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Biological and translational implications of replication repair deficiency and hypermutation in human cancer

Biological and translational implications of replication repair deficiency and hypermutation in human cancer
人类癌症中复制修复缺陷和超突变的生物学和转化意义
批准号：
369955
负责人：
Tabori Uri
金额：
$69.66万
依托单位：
Hospital for Sick Children (Toronto)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2017
资助国家：
加拿大
项目状态：
已结题
起止时间：
2017-09-01 至 2022-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=369955&lang=en
关键词：
Animal Model Cancer Cancer Predisposrition Hypermutation Microsatelite Instability Mismatch Repair Deficiency Treatment

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中文摘要
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英文摘要
The human cell needs to duplicate each DNA molecule to enable it to divide into 2 daughter cells. This important process is called DNA replication and is not mistake free. Indeed, up to a third of mutations which result in cancer occur during this replica
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Uncovering the mechanism and impact of novel genetic and epigenetic promoter alterations on tissue-specific mismatch repair deficient cancers
Dissecting the origins and microenvironment of replication repair deficient hypermutant gliomas for novel immune based therapies
Translating genomic discoveries to cure ultrahypermutant mismatch repair deficient brain tumors
Novel implications of THOR hypermethylation in telomere maintenance and gliomageneis.
国内基金
海外基金
中国北方人群肺癌患者Cancer/Testis抗原表达谱绘制表位鉴定及功能性抗原特异性CTL制备研究
  • 批准号：
    81673007
  • 项目类别：
    面上项目
  • 资助金额：
    54.0万元
  • 批准年份：
    2016
  • 负责人：
    金时
  • 依托单位：
    哈尔滨医科大学