课题基金 / 基金详情

Uncovering the mechanism and impact of novel genetic and epigenetic promoter alterations on tissue-specific mismatch repair deficient cancers

Uncovering the mechanism and impact of novel genetic and epigenetic promoter alterations on tissue-specific mismatch repair deficient cancers
揭示新型遗传和表观遗传启动子改变对组织特异性错配修复缺陷癌症的机制和影响
批准号：
470018
负责人：
Tabori Uri
金额：
$83.6万
依托单位：
Hospital for Sick Children (Toronto)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2022
资助国家：
加拿大
项目状态：
未结题
起止时间：
2022-09-01 至 2027-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=470018&lang=en
关键词：
Cancer Predisposition Colon Cancers Glioma Hypermutation Mismatch Repair Deficiency Promoter Hypermethylation Promoter Mutation

项目摘要

项目成果

Tabori Uri的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
When the cells of our body divide to create new cells, the DNA is copied. This process is prone to mistakes, known as DNA mutations. Normal cells are able to repair these mistakes, however, in patients with inherited genetic alterations in DNA damage repa
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Dissecting the origins and microenvironment of replication repair deficient hypermutant gliomas for novel immune based therapies
Biological and translational implications of replication repair deficiency and hypermutation in human cancer
Translating genomic discoveries to cure ultrahypermutant mismatch repair deficient brain tumors
Novel implications of THOR hypermethylation in telomere maintenance and gliomageneis.
海外基金