Uncovering the mechanism and impact of novel genetic and epigenetic promoter alterations on tissue-specific mismatch repair deficient cancers
揭示新型遗传和表观遗传启动子改变对组织特异性错配修复缺陷癌症的机制和影响
基本信息
- 批准号:470018
- 负责人:
- 金额:$ 83.6万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Operating Grants
- 财政年份:2022
- 资助国家:加拿大
- 起止时间:2022-09-01 至 2027-09-01
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
When the cells of our body divide to create new cells, the DNA is copied. This process is prone to mistakes, known as DNA mutations. Normal cells are able to repair these mistakes, however, in patients with inherited genetic alterations in DNA damage repa
当我们身体的细胞分裂产生新细胞时,DNA被复制。这个过程很容易出错,称为DNA突变。正常细胞能够修复这些错误,然而,在DNA损伤修复中遗传基因改变的患者中,
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Tabori Uri其他文献
Tabori Uri的其他文献
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{{ truncateString('Tabori Uri', 18)}}的其他基金
Dissecting the origins and microenvironment of replication repair deficient hypermutant gliomas for novel immune based therapies
剖析复制修复缺陷型超突变神经胶质瘤的起源和微环境,用于新型免疫疗法
- 批准号:
444717 - 财政年份:2021
- 资助金额:
$ 83.6万 - 项目类别:
Operating Grants
Biological and translational implications of replication repair deficiency and hypermutation in human cancer
人类癌症中复制修复缺陷和超突变的生物学和转化意义
- 批准号:
369955 - 财政年份:2017
- 资助金额:
$ 83.6万 - 项目类别:
Operating Grants
Translating genomic discoveries to cure ultrahypermutant mismatch repair deficient brain tumors
转化基因组发现来治疗超超突变错配修复缺陷脑肿瘤
- 批准号:
332326 - 财政年份:2015
- 资助金额:
$ 83.6万 - 项目类别:
Operating Grants
Novel implications of THOR hypermethylation in telomere maintenance and gliomageneis.
THOR 超甲基化在端粒维持和神经胶质细胞生成中的新意义。
- 批准号:
304515 - 财政年份:2014
- 资助金额:
$ 83.6万 - 项目类别:
Operating Grants
Clinical and biological implications of monoallelic gene expression in pediatric malignant brain tumors.
小儿恶性脑肿瘤中单等位基因表达的临床和生物学意义。
- 批准号:
252418 - 财政年份:2012
- 资助金额:
$ 83.6万 - 项目类别:
Operating Grants
Prediction and Prevention of glioma recurrence by targeting telomere dependent self-renewal capacity of tumor initiating cells.
通过靶向肿瘤起始细胞的端粒依赖性自我更新能力来预测和预防神经胶质瘤复发。
- 批准号:
210910 - 财政年份:2010
- 资助金额:
$ 83.6万 - 项目类别:
Operating Grants
Combined telomerase inhibition and drug screen as novel therapies for tumor initiating cells in pediatric nervous system tumors.
结合端粒酶抑制和药物筛选作为小儿神经系统肿瘤肿瘤起始细胞的新疗法。
- 批准号:
192068 - 财政年份:2009
- 资助金额:
$ 83.6万 - 项目类别:
Salary Programs
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