Roles of isolation, secondary contact and gene flow in diversification and speciation.
隔离、二次接触和基因流在多样化和物种形成中的作用。
基本信息
- 批准号:RGPIN-2014-06150
- 负责人:
- 金额:$ 3.06万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2017
- 资助国家:加拿大
- 起止时间:2017-01-01 至 2018-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
One of the most enduring goals in evolutionary biology is to understand how new species arise. The traditional view, popularized by 20th Century evolutionary biologist Ernst Mayr, emphasized a geographic view of speciation where most new species arise or at least begin through physical and thus genetic isolation of ancestral populations. Recent theoretical and empirical work has moved away from these geography-based views of speciation to ones that emphasize mechanism (e.g. selection driving ecological divergence) producing important insights into how new species arise. However, our own NSERC-funded research over the last 5 years highlights the pervasiveness of both geographic isolation and subsequent secondary contact in the histories of most vertebrate species, mirroring comprehensive reviews of the phylogeographic literature. Thus, the long-term objective of my NSERC-funded research over the next 5 years is to quantify the role of such long-term geographical isolation, and consequences of range dynamics, and especially secondary contact in the evolution and maintenance of species.My proposed NSERC research focuses on a single temperate eastern North American frog, the spring peeper (Pseudacris crucifer), which I am developing into a model system for speciation studies. Our published work suggests that the spring peeper has a dynamic evolutionary history with 6 well-supported evolutionary lineages that originated in distinct, isolated refugia between 11 and 3 million years before present. Different lineage pairs with disparate times of divergence have come into secondary contact in different parts of the species’ range, presumably within the last 10-15,000 years. In the proposed research, my students and I will combine large-scale genomic and geographic information system (GIS) data, new statistical and modeling techniques, bioacoustical analysis, and playback and hybridization experiments to address a series of research questions on speciation: (i) What is the relation of divergence times between evolutionary lineages and patterns of reproductive isolation, the hallmark of biological species? (ii) What do genomic data say about the patterns of gene flow among lineages over the entire history of this species? (iii) Does secondary contact of closely-related lineages result in more effective reproductive barriers, either to diminish acoustic interference of male advertisement calls (used by females in mate choice), or to prevent maladaptive hybridization? (iv) How might marked differences in the acoustic environment or seasonality shape the outcomes of secondary contact between diverging lineages? (v) What are the various fitness costs of hybridization between lineages?My research program helps put Canada at the forefront of speciation research, bringing together perspectives from biogeography, genomics, landscape ecology, and ecological genetics. It provides important inputs into conservation strategies for Canadian species at risk, for example how best to retain evolutionary potential for future diversification and adaptation, and whether phylogeographic divisions merit separate conservation designation. The training program that I outline will provide premier opportunities for a minimum of 4 PhD, 3 MSc and 25 BSc students in genetics, quantitative methods, GIS, and professional development. As I have done in the past, I will leverage expertise developed with my NSERC research to seek additional funding and opportunities for applied landscape genetic & conservation studies of Canadian species at risk.
进化生物学最持久的目标之一是了解新物种是如何产生的。传统观点,由20世纪世纪进化生物学家恩斯特·迈尔推广,强调物种形成的地理观点,大多数新物种的出现或至少开始是通过祖先种群的物理隔离和遗传隔离。最近的理论和实证工作已经从这些基于地理的物种形成观点转向强调机制(例如选择驱动生态分歧)的观点,从而对新物种如何出现产生重要见解。然而,我们自己的NSERC资助的研究在过去5年中突出了地理隔离和随后的二次接触在大多数脊椎动物物种的历史中的普遍性,反映了对地理学文献的全面回顾。因此,我的NSERC资助的研究在未来5年的长期目标是量化这种长期地理隔离的作用,以及范围动态的后果,特别是在物种的进化和维持中的二次接触。(Pseudacris crucifer),我正在将其开发为物种形成研究的模型系统。我们发表的工作表明,春季偷窥者有一个动态的进化历史,有6个支持良好的进化谱系,起源于1100万至300万年前的独特的,孤立的避难所。不同的谱系对与不同的时间分歧已经进入了第二次接触的不同部分的物种的范围,大概在过去的10- 15000年。在拟议的研究中,我和我的学生将结合联合收割机大规模的基因组和地理信息系统(GIS)数据,新的统计和建模技术,生物声学分析,回放和杂交实验,以解决一系列的研究问题的物种形成:(一)什么是进化谱系和模式的生殖隔离,生物物种的标志之间的分歧时间的关系?(ii)基因组数据对这个物种整个历史中世系之间的基因流动模式有什么说明?(iii)密切相关的血统的二次接触是否会导致更有效的生殖障碍,以减少男性广告呼叫的声音干扰(女性在择偶时使用),或防止适应不良的杂交?(iv)声学环境或季节性的显著差异如何塑造不同谱系之间二次接触的结果?(v)血统间杂交的各种适应性成本是什么?我的研究计划有助于把加拿大在物种形成研究的最前沿,汇集从地理学,基因组学,景观生态学和生态遗传学的观点。它为加拿大濒危物种的保护战略提供了重要的投入,例如如何最好地保留未来多样化和适应的进化潜力,以及不同地理分区是否值得单独的保护指定。我概述的培训计划将为遗传学,定量方法,GIS和专业发展方面的至少4名博士,3名硕士和25名理科学生提供首要机会。正如我过去所做的那样,我将利用我的NSERC研究开发的专业知识,为加拿大濒危物种的应用景观遗传和保护研究寻求额外的资金和机会。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Lougheed, Stephen其他文献
Lougheed, Stephen的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Lougheed, Stephen', 18)}}的其他基金
The roles of geographical isolation, secondary contact, and mitonuclear disequilibrium in speciation
地理隔离、次级接触和线粒体核不平衡在物种形成中的作用
- 批准号:
RGPIN-2019-04920 - 财政年份:2022
- 资助金额:
$ 3.06万 - 项目类别:
Discovery Grants Program - Individual
The roles of geographical isolation, secondary contact, and mitonuclear disequilibrium in speciation
地理隔离、次级接触和线粒体核不平衡在物种形成中的作用
- 批准号:
RGPIN-2019-04920 - 财政年份:2021
- 资助金额:
$ 3.06万 - 项目类别:
Discovery Grants Program - Individual
Helping teachers integrate environmental science and Indigenous traditional knowledge in a rapidly changing world
帮助教师在快速变化的世界中整合环境科学和土著传统知识
- 批准号:
556845-2020 - 财政年份:2021
- 资助金额:
$ 3.06万 - 项目类别:
PromoScience
Helping teachers integrate environmental science and Indigenous traditional knowledge in a rapidly changing world
帮助教师在快速变化的世界中整合环境科学和土著传统知识
- 批准号:
556845-2020 - 财政年份:2020
- 资助金额:
$ 3.06万 - 项目类别:
PromoScience
Digital PCR infrastructure to enhance research and HQP training in biology
数字 PCR 基础设施可加强生物学研究和 HQP 培训
- 批准号:
RTI-2021-00120 - 财政年份:2020
- 资助金额:
$ 3.06万 - 项目类别:
Research Tools and Instruments
The roles of geographical isolation, secondary contact, and mitonuclear disequilibrium in speciation
地理隔离、次级接触和线粒体核不平衡在物种形成中的作用
- 批准号:
RGPIN-2019-04920 - 财政年份:2020
- 资助金额:
$ 3.06万 - 项目类别:
Discovery Grants Program - Individual
High performance computing infrastructure for evolutionary biology, spatial ecology, and conservation biology
用于进化生物学、空间生态学和保护生物学的高性能计算基础设施
- 批准号:
RTI-2020-00738 - 财政年份:2019
- 资助金额:
$ 3.06万 - 项目类别:
Research Tools and Instruments
Helping teachers integrate environmental science & Indigenous traditional knowledge in a rapidly changing world
帮助教师整合环境科学
- 批准号:
545329-2019 - 财政年份:2019
- 资助金额:
$ 3.06万 - 项目类别:
PromoScience
The roles of geographical isolation, secondary contact, and mitonuclear disequilibrium in speciation
地理隔离、次级接触和线粒体核不平衡在物种形成中的作用
- 批准号:
RGPIN-2019-04920 - 财政年份:2019
- 资助金额:
$ 3.06万 - 项目类别:
Discovery Grants Program - Individual
Roles of isolation, secondary contact and gene flow in diversification and speciation.
隔离、二次接触和基因流在多样化和物种形成中的作用。
- 批准号:
RGPIN-2014-06150 - 财政年份:2018
- 资助金额:
$ 3.06万 - 项目类别:
Discovery Grants Program - Individual
相似海外基金
Cafe Move: A Novel Program for Prevention of Age-Related Physical Frailty
Cafe Move:预防与年龄相关的身体虚弱的新计划
- 批准号:
10861960 - 财政年份:2023
- 资助金额:
$ 3.06万 - 项目类别:
Development and Pilot Study of Primary Care Loneliness Interventions to Prevent Suicide
预防自杀的初级保健孤独干预措施的开发和试点研究
- 批准号:
10646959 - 财政年份:2023
- 资助金额:
$ 3.06万 - 项目类别:
Optimizing a Social Connectedness Intervention for Young Adults with Cancer
优化年轻癌症患者的社会联系干预
- 批准号:
10734095 - 财政年份:2023
- 资助金额:
$ 3.06万 - 项目类别:
Healthy Relationships on the Autism Spectrum: Feasibility and Target Engagement
自闭症谱系的健康关系:可行性和目标参与
- 批准号:
10574808 - 财政年份:2023
- 资助金额:
$ 3.06万 - 项目类别:
Translational genomics in gout: From GWAS signal to mechanism
痛风的转化基因组学:从 GWAS 信号到机制
- 批准号:
10735151 - 财政年份:2023
- 资助金额:
$ 3.06万 - 项目类别:
HomeVENT (Home Values and Experiences Navigation Track)
HomeVENT(家庭价值观和体验导航轨道)
- 批准号:
10734147 - 财政年份:2023
- 资助金额:
$ 3.06万 - 项目类别:
Examining a Multicomponent Intervention to Improve HIV Health among Black Men in Southern Ending the HIV Epidemic in the U.S. Jurisdictions
检查改善南部黑人男性艾滋病毒健康的多成分干预措施,结束美国司法管辖区的艾滋病毒流行
- 批准号:
10744410 - 财政年份:2023
- 资助金额:
$ 3.06万 - 项目类别:
Self-management Intervention for Reducing Epilepsy Burden among Ugandans with Epilepsy
减轻乌干达癫痫患者癫痫负担的自我管理干预措施
- 批准号:
10740917 - 财政年份:2023
- 资助金额:
$ 3.06万 - 项目类别:
Empowering Formerly Homeless Older Adults to Engage in Advance Care Planning in Permanent Supportive Housing (ACP-PSH): An RCT
帮助以前无家可归的老年人参与永久支持性住房中的预先护理计划 (ACP-PSH):一项随机对照试验
- 批准号:
10639204 - 财政年份:2023
- 资助金额:
$ 3.06万 - 项目类别:
COVID-19 Impacts on Health Services and Social Support for Pregnant and Postpartum People in Prison
COVID-19 对监狱中孕妇和产后人员健康服务和社会支持的影响
- 批准号:
10669448 - 财政年份:2023
- 资助金额:
$ 3.06万 - 项目类别: