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The physical underpinnings of intrinsically disordered proteins: conformations, dynamics and interactions

The physical underpinnings of intrinsically disordered proteins: conformations, dynamics and interactions
本质无序蛋白质的物理基础：构象、动力学和相互作用
批准号：
RGPIN-2017-06030
负责人：
Gradinaru, Claudiu
金额：
$3.28万
依托单位：
University of Toronto
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2017
资助国家：
加拿大
项目状态：
已结题
起止时间：
2017-01-01 至 2018-12-31
来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632369
关键词：
physicalunderpinningsintrinsicallydisorderedproteins

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英文摘要
Complex dynamic behavior dictates many key aspects of protein function. Intrinsically disordered proteins (IDPs), which are involved in cancer and neurodegenerative diseases, exhibit conformational changes on nanosecond to millisecond timescales which are essential for their regulatory mechanisms. Despite an intense multidisciplinary focus on IDPs in recent years, a reasonable understanding of the physical mechanisms underlying their structural disorder and the dynamic nature of their interactions is still lacking.
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The physical underpinnings of intrinsically disordered proteins: conformations, dynamics and interactions
  • 批准号：
    RGPIN-2017-06030
  • 项目类别：
    Discovery Grants Program - Individual
  • 资助金额：
    $6.56万
  • 财政年份：
    2021
  • 负责人：
    Gradinaru, Claudiu
  • 依托单位：
    University of Toronto
The physical underpinnings of intrinsically disordered proteins: conformations, dynamics and interactions
  • 批准号：
    RGPIN-2017-06030
  • 项目类别：
    Discovery Grants Program - Individual
  • 资助金额：
    $3.28万
  • 财政年份：
    2020
  • 负责人：
    Gradinaru, Claudiu
  • 依托单位：
    University of Toronto
The physical underpinnings of intrinsically disordered proteins: conformations, dynamics and interactions
  • 批准号：
    RGPIN-2017-06030
  • 项目类别：
    Discovery Grants Program - Individual
  • 资助金额：
    $3.28万
  • 财政年份：
    2019
  • 负责人：
    Gradinaru, Claudiu
  • 依托单位：
    University of Toronto
The physical underpinnings of intrinsically disordered proteins: conformations, dynamics and interactions
  • 批准号：
    RGPIN-2017-06030
  • 项目类别：
    Discovery Grants Program - Individual
  • 资助金额：
    $3.28万
  • 财政年份：
    2018
  • 负责人：
    Gradinaru, Claudiu
  • 依托单位：
    University of Toronto
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