The physical underpinnings of intrinsically disordered proteins: conformations, dynamics and interactions

本质无序蛋白质的物理基础：构象、动力学和相互作用

• 批准号: RGPIN-2017-06030
• 负责人: Gradinaru, Claudiu
• 金额: $ 3.28万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632369
• 关键词: physical; underpinnings; intrinsically; disordered; proteins

Complex dynamic behavior dictates many key aspects of protein function. Intrinsically disordered proteins (IDPs), which are involved in cancer and neurodegenerative diseases, exhibit conformational changes on nanosecond to millisecond timescales which are essential for their regulatory mechanisms. Despite an intense multidisciplinary focus on IDPs in recent years, a reasonable understanding of the physical mechanisms underlying their structural disorder and the dynamic nature of their interactions is still lacking.

复杂的动力学行为决定了蛋白质功能的许多关键方面。与癌症和神经退行性疾病有关的内源性无序蛋白（IDP）在纳秒至毫秒的时间尺度上表现出构象变化，这对其调节机制至关重要。尽管近年来对国内流离失所者问题进行了多学科的密切关注，但仍然缺乏对其结构紊乱的物理机制及其相互作用的动态性质的合理理解。