Exploring the chemistry of ferrocene bioconjugates.

探索二茂铁生物共轭物的化学性质。

• 批准号: RGPIN-2016-06122
• 负责人: Kraatz, HeinzBernhard
• 金额: $ 5.46万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632462
• 关键词: Exploring; chemistry; ferrocene; bioconjugates.

This NSERC discovery grant proposal focuses on ferrocene-peptide conjugates, their properties in solution and on surfaces, including their electrochemical and materials properties. In particular, we are exploiting the ability of ferrocene peptides to associate to form gel materials based on a nanofibrillar architecture. Such gel materials incorporate large amounts of solvents in their matrix. In this research program, we are exploring factors leading to aggregation and gel formation, among them is the influence of peptide chirality and self-sorting behavior of ferrocene peptide conjugates.

这个NSERC的发现资助提案侧重于二茂铁-肽缀合物，它们在溶液和表面上的特性，包括它们的电化学和材料特性。特别是，我们正在利用二茂铁肽的能力，以形成基于纳米纤维结构的凝胶材料。这种凝胶材料在其基质中掺入大量溶剂。在本研究计划中，我们正在探索导致聚集和凝胶形成的因素，其中包括肽手性和二茂铁肽缀合物的自分选行为的影响。