Software development program for the fast prototyping of applications of focused ultrasound guided by magnetic resonance imaging

用于磁共振成像引导聚焦超声应用快速原型设计的软件开发程序

• 批准号: 386715-2013
• 负责人: Pichardo, Samuel
• 金额: $ 1.53万
• 依托单位: Lakehead University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=633306
• 关键词: Software; development; program; fast; prototyping

High Intensity Focused ultrasound (HIFU) is a technique where mechanical energy is concentrated in a small volume. This concentration can be used to induce several bio-effects in biological tissue including absorption, radiation-force streaming or cavitation. Magnetic resonance imaging (MRI) provides a precise volumetric image reconstruction and has become the preferred modality to guide HIFU since MRI can be used to monitor the absorption effects induced by HIFU. The combination of MRI and HIFU is known as MRgHIFU. Even if HIFU has proven being an effective option for therapeutic applications such as the treatment of uterine fibroids, a considerable amount of basic research has to be conducted to overcome challenges as reaching targets behind the rib cage and compensate organ movement. This research program will develop a technological platform for the fast prototyping of MRgHIFU applications. Traditionally, most of models and imaging techniques have to be tested offline. The proposed platform will integrate elements already developed in my laboratory for the control of the MRI scanner and FUs devices located in our facilities. Also, I have developed several mathematical models for ultrasound propagation and bio-effects running in graphic processors. These models will be upgraded to increase precision of prediction, such the use of methods based on spectral decomposition for sound propagation and prediction of bio-effects in deformable organs. The proposed program will continue to offer opportunities for graduate studies in the areas of control of devices, image processing, mathematical modeling and high performance computing. The type of projects that will be possible with this platform will include closed-loop control algorithms for hyperthermia effects, MRI-based elasticity imaging for control of FUs energy and tracking of moving objects. The impact of this research program in the area of MRgHIFU and MRI will be considerable since this program will establish a very efficient technological platform to test and optimize the new generation of applications of MRgHIFU.

高强度聚焦超声 (HIFU) 是一种将机械能集中在小体积内的技术。该浓度可用于在生物组织中诱导多种生物效应，包括吸收、辐射力流或空化。磁共振成像 (MRI) 提供精确的体积图像重建，并且已成为引导 HIFU 的首选方式，因为 MRI 可用于监测 HIFU 引起的吸收效应。 MRI 和 HIFU 的组合称为 MRgHIFU。即使 HIFU 已被证明是治疗子宫肌瘤等治疗应用的有效选择，仍需要进行大量基础研究来克服挑战，例如到达胸腔后面的目标并补偿器官运动。该研究项目将开发一个用于 MRgHIFU 应用快速原型设计的技术平台。传统上，大多数模型和成像技术都必须进行离线测试。拟议的平台将集成我的实验室已开发的元素，用于控制我们设施中的 MRI 扫描仪和 FU 设备。此外，我还开发了几个在图形处理器中运行的超声波传播和生物效应的数学模型。这些模型将进行升级以提高预测精度，例如使用基于频谱分解的方法来进行声音传播和预测可变形器官的生物效应。拟议的项目将继续为设备控制、图像处理、数学建模和高性能计算领域的研究生学习提供机会。该平台可实现的项目类型包括用于热疗效应的闭环控制算法、用于控制 FU 能量的基于 MRI 的弹性成像以及移动物体的跟踪。该研究项目在 MRgHIFU 和 MRI 领域的影响将是相当大的，因为该项目将建立一个非常有效的技术平台来测试和优化 MRgHIFU 的新一代应用。