Software development program for the fast prototyping of applications of focused ultrasound guided by magnetic resonance imaging

用于磁共振成像引导聚焦超声应用快速原型设计的软件开发程序

• 批准号: 386715-2013
• 负责人: Pichardo, Samuel
• 金额: $ 1.53万
• 依托单位: Lakehead University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=573019
• 关键词: Software; development; program; fast; prototyping

High Intensity Focused ultrasound (HIFU) is a technique where mechanical energy is concentrated in a small volume. This concentration can be used to induce several bio-effects in biological tissue including absorption, radiation-force streaming or cavitation. Magnetic resonance imaging (MRI) provides a precise volumetric image reconstruction and has become the preferred modality to guide HIFU since MRI can be used to monitor the absorption effects induced by HIFU. The combination of MRI and HIFU is known as MRgHIFU. Even if HIFU has proven being an effective option for therapeutic applications such as the treatment of uterine fibroids, a considerable amount of basic research has to be conducted to overcome challenges as reaching targets behind the rib cage and compensate organ movement. This research program will develop a technological platform for the fast prototyping of MRgHIFU applications. Traditionally, most of models and imaging techniques have to be tested offline. The proposed platform will integrate elements already developed in my laboratory for the control of the MRI scanner and FUs devices located in our facilities. Also, I have developed several mathematical models for ultrasound propagation and bio-effects running in graphic processors. These models will be upgraded to increase precision of prediction, such the use of methods based on spectral decomposition for sound propagation and prediction of bio-effects in deformable organs. The proposed program will continue to offer opportunities for graduate studies in the areas of control of devices, image processing, mathematical modeling and high performance computing. The type of projects that will be possible with this platform will include closed-loop control algorithms for hyperthermia effects, MRI-based elasticity imaging for control of FUs energy and tracking of moving objects. The impact of this research program in the area of MRgHIFU and MRI will be considerable since this program will establish a very efficient technological platform to test and optimize the new generation of applications of MRgHIFU.

高强度聚焦超声（HIFU）是一种机械能集中在少量体积的技术。该浓度可用于诱导生物组织中的多种生物效应，包括吸收，辐射冲流或空化。 磁共振成像（MRI）提供了精确的体积图像重建，并已成为指导HIFU的首选模态，因为MRI可用于监测HIFU诱导的吸收效应。 MRI和HIFU的组合被称为Mrghifu。即使事实证明HIFU是治疗子宫肌瘤等治疗应用的有效选择，也必须进行大量的基础研究，以克服挑战，因为挑战在肋骨笼子背后达到目标并补偿器官运动。 该研究计划将开发一个技术平台，用于快速的MRGHIFU应用程序。传统上，大多数模型和成像技术都必须离线测试。拟议的平台将集成我的实验室中已经开发的要素，以控制我们设施中的MRI扫描仪和FUS设备。 另外，我开发了几种数学模型，用于超声传播和在图形处理器中运行的生物效应。这些模型将被升级以提高预测的精度，例如基于光谱分解的方法用于可变形器官中生物效应的声音传播和预测。 拟议的计划将继续在设备控制，图像处理，数学建模和高性能计算领域提供研究生学习的机会。该平台将可能的项目类型包括用于高温效果的闭环控制算法，基于MRI的弹性成像，用于控制FUS能量和移动对象的跟踪。该研究计划在MRGHIFU和MRI领域的影响将是相当大的，因为该计划将建立一个非常有效的技术平台，以测试和优化MRGHIFU的新一代应用程序。