Adaptive optics applied to laser femtosecond filamentation for radiation sciences applications

高强度聚焦超短激光脉冲常用于生物医学研究和治疗。最近，超短脉冲激光不仅用于双光子显微镜，而且还用于通过完整颅骨对小鼠大脑进行高分辨率体内成像。在治疗方面，我们已经展示了基于飞秒红外激光束照射的新的癌症放射治疗（R。Meesat等人PNAS第109卷，E2508-E2513（2012），专利USA 13/580，038（2012），PCT W 02011/109907 Al（2011），专利CA PCT/CA 2011/000273，韩国PCT 5-2012-048051-9（2011））。在放射生物学和放射疗法中，超短激光脉冲在称为双折射的非线性光子过程中产生低能电子（LEE），称为低密度等离子体。这种采用自适应光学方法的激光诱导LEE可用于生物功能调节。为了实现低密度等离子体的空间微观控制，我们将引入可编程空间光调制器（SLM）。自适应光学方法将产生使用SLM，并将被应用于控制的飞秒激光照射的放射生物学和放射治疗的应用。LEE飞秒等离子体沉积的微观控制可以自动调节，并且与特定的超短激光无关。这种激光等离子体微束将用于未来的治疗（放射生物学和放射疗法），成像和更广泛的生物功能调制。

Focused ultrashort laser pulses with high intensity is often used in biomedical research and treatment. Recently ultrashort-pulsed lasers have been used not only for two-photons microscopy but also in high resolution in vivo imaging of mouse brain through the intact skull. In therapy, we have shown new cancer radiotherapy based on femtosecond IR laser-beam filamentation (R. Meesat et al. PNAS vol. 109, E2508-E2513 (2012), Patent USA 13/580,038 (2012), PCT WO2011/109907 A1 (2011), Patent CA PCT/CA2011/000273, Korean PCT 5-2012-048051-9 (2011)). In radiobiology and radiotherapy ultrashort laser pulses generate low energy electrons (LEE), known as low-density plasma in a nonlinear photonic process called filamentation. This laser-induced LEE using adaptive optics method can be used for biological function modulation. To achieve this spatially microscopic control of the low-density plasma, we will introduce a programmable Spatial Light Modulator (SLM). An adaptive optics method will be generated using the SLM and will be applied to the control of the femtosecond laser filamentation for radiobiology and radiotherapy applications. The microscopic control of the LEE femtosecond plasma deposition can be auto-regulated and independent of the specific ultrashort laser. This laser plasma micro-beam will be used for future treatments (radiobiology and radiotherapy), imaging and more generally modulation of biological functions.