Adaptive optics applied to laser femtosecond filamentation for radiation sciences applications

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***Focused ultrashort laser pulses with high intensity is often used in biomedical research and treatment. Recently ultrashort-pulsed lasers have been used not only for two-photons microscopy but also in high resolution in vivo imaging of mouse brain through the intact skull. In therapy, we have shown new cancer radiotherapy based on femtosecond IR laser-beam filamentation (R. Meesat et al. PNAS vol. 109, E2508-E2513 (2012), Patent USA 13/580,038 (2012), PCT WO2011/109907 A1 (2011), Patent CA PCT/CA2011/000273, Korean PCT 5-2012-048051-9 (2011)). In radiobiology and radiotherapy ultrashort laser pulses generate low energy electrons (LEE), known as low-density plasma in a nonlinear photonic process called filamentation. This laser-induced LEE using adaptive optics method can be used for biological function modulation. To achieve this spatially microscopic control of the low-density plasma, we will introduce a programmable Spatial Light Modulator (SLM). An adaptive optics method will be generated using the SLM and will be applied to the control of the femtosecond laser filamentation for radiobiology and radiotherapy applications. The microscopic control of the LEE femtosecond plasma deposition can be auto-regulated and independent of the specific ultrashort laser. This laser plasma micro-beam will be used for future treatments (radiobiology and radiotherapy), imaging and more generally modulation of biological functions. ***Filaments are analogue of tracks in radiation science with an important difference: diameter of filaments in condensed matter (water), are around 5.5 m. In general, the Gaussian profile intensity of the laser beam is not smooth will produced a bunching of multiple filaments. The SLM adaptive optics method will trig a self-regulated monofilament independent of the femtosecond laser. The real time microscopic basis of the dose equivalent femtosecond energy deposition of radiation (femtosecond Dose deposition) is the general project aim. We will measure the effects of this auto-regulated monofilament on biomolecules of radiobiological interest. For the first time, it will be possible to image a tissue, choosing an real time intervention (reversible low-density plasma photomodulation, or irreversible low-density plasma radiotherapy) using the same fs laser system modulated by and SLM adaptive optics method. *****