Adaptive optics applied to laser femtosecond filamentation for radiation sciences applications

自适应光学应用于辐射科学应用的激光飞秒成丝

• 批准号: RGPIN-2016-05139
• 负责人: Houde, Daniel
• 金额: $ 1.6万
• 依托单位: Université de Sherbrooke
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=708953
• 关键词: Adaptive; optics; applied; laser; femtosecond

Focused ultrashort laser pulses with high intensity is often used in biomedical research and treatment. Recently ultrashort-pulsed lasers have been used not only for two-photons microscopy but also in high resolution in vivo imaging of mouse brain through the intact skull. In therapy, we have shown new cancer radiotherapy based on femtosecond IR laser-beam filamentation (R. Meesat et al. PNAS vol. 109, E2508-E2513 (2012), Patent USA 13/580,038 (2012), PCT WO2011/109907 A1 (2011), Patent CA PCT/CA2011/000273, Korean PCT 5-2012-048051-9 (2011)). In radiobiology and radiotherapy ultrashort laser pulses generate low energy electrons (LEE), known as low-density plasma in a nonlinear photonic process called filamentation. This laser-induced LEE using adaptive optics method can be used for biological function modulation. To achieve this spatially microscopic control of the low-density plasma, we will introduce a programmable Spatial Light Modulator (SLM). An adaptive optics method will be generated using the SLM and will be applied to the control of the femtosecond laser filamentation for radiobiology and radiotherapy applications. The microscopic control of the LEE femtosecond plasma deposition can be auto-regulated and independent of the specific ultrashort laser. This laser plasma micro-beam will be used for future treatments (radiobiology and radiotherapy), imaging and more generally modulation of biological functions. Filaments are analogue of tracks in radiation science with an important difference: diameter of filaments in condensed matter (water), are around 5.5 m. In general, the Gaussian profile intensity of the laser beam is not smooth will produced a bunching of multiple filaments. The SLM adaptive optics method will trig a self-regulated monofilament independent of the femtosecond laser. The real time microscopic basis of the dose equivalent femtosecond energy deposition of radiation (femtosecond Dose deposition) is the general project aim. We will measure the effects of this auto-regulated monofilament on biomolecules of radiobiological interest. For the first time, it will be possible to image a tissue, choosing an real time intervention (reversible low-density plasma photomodulation, or irreversible low-density plasma radiotherapy) using the same fs laser system modulated by and SLM adaptive optics method.

聚焦的高强度超短激光脉冲常用于生物医学研究和治疗。近年来，超短脉冲激光不仅用于双光子显微镜，而且还用于通过完整颅骨对小鼠大脑进行高分辨率的活体成像。在治疗方面，我们已经展示了基于飞秒红外激光束细丝的新型癌症放疗（R. Meesat等）。PNAS vol. 109, E2508-E2513(2012)，美国专利13/580,038 (2012),PCT WO2011/109907 A1（2011)，中国专利PCT/CA2011/000273，韩国专利PCT 5-2012-048051-9(2011)）。在放射生物学和放射治疗中，超短激光脉冲在非线性光子过程中产生低能量电子（LEE），称为低密度等离子体。采用自适应光学方法的激光诱导LEE可用于生物功能调制。为了实现对低密度等离子体的空间微观控制，我们将引入可编程空间光调制器（SLM）。使用SLM将产生一种自适应光学方法，并将应用于放射生物学和放射治疗应用的飞秒激光灯丝的控制。飞秒等离子体沉积的显微控制可以自动调节，不依赖于特定的超短激光。这种激光等离子体微束将用于未来的治疗（放射生物学和放射治疗）、成像和更普遍的生物功能调节。