Comprehensive Experimental and Numerical Studies of Pharmaceutical Aerosol Devices

药用气雾剂装置的综合实验和数值研究

• 批准号: RGPIN-2016-06239
• 负责人: Matida, Edgar
• 金额: $ 1.89万
• 依托单位: Carleton University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=638459
• 关键词: Comprehensive; Experimental; Numerical; Studies; Pharmaceutical

Pressurized metered-dose inhalers (pMDIs) or “puffers”, dry powder inhalers (DPIs), and nebulizers are normally used in the treatment of lung diseases, such as asthma and bronchitis. Statistics from Lung Associations indicate that up to approximately 10% of the population may suffer from respiratory illnesses requiring treatment in part of their lives. Inhaler devices produce very complex turbulent flows and ideal medication delivery remains a challenging engineering problem. Considerable amounts of aerosol medication generated from the pMDIs are deposited and lost on the walls of the upper airways (mouth-throat-trachea) before reaching the target (or the lungs), resulting in considerable medication losses from a single dosage (Fink, 2000). Add-on spacers (normally cylindrical chambers) are devices that are attached to the pMDIs and will enhance the total amount of medication delivered to the lungs.

加压计量吸入器（pMDI）或“膨化器”、干粉吸入器（DPI）和雾化器通常用于治疗肺部疾病，例如哮喘和支气管炎。肺协会的统计数据表明，高达约10%的人口可能患有呼吸系统疾病，需要在他们的生活中接受治疗。吸入器装置产生非常复杂的湍流，理想的药物输送仍然是一个具有挑战性的工程问题。pMDI产生的大量气雾剂药物在到达目标（或肺部）之前沉积并损失在上气道（口-喉-气管）壁上，导致单次给药的药物损失相当大（Fink，2000）。附加间隔器（通常为圆柱形腔室）是连接到pMDI的装置，将增加输送到肺部的药物总量。