Aerosol Deposition Measurements and Numerical Simulations in Extra-thoracic Airways using the Respimat® Inhaler with an ODAPT(TM) Add-on Mask Adapter

使用带有 ODAPT(TM) 附加面罩适配器的 Respimat® 吸入器​​进行胸外气道中的气溶胶沉积测量和数值模拟

• 批准号: 507665-2017
• 负责人: Matida, Edgar
• 金额: $ 1.82万
• 依托单位: Carleton University
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=639987
• 关键词: Aerosol; Deposition; Measurements; Numerical; Simulations

MMSI (McArthur Medical Sales Inc., Rockton, ON) developed an add-on adapter to connect the Respimatinhaler to commercially available masks that will facilitate the inhalation of ashtma medication by certainpatients, normally seniors and children, who may normally lack coordination between actuation and inhalation.The effect of introducing the adapter (and mask) on the inhalation performance (medication delivery to thelungs) will be investigated in-vitro (indirectly using idealized mouth-throat-trachea replicas) and comparedagainst the efficiency of the Respimat inhaler alone. Deposition numerical simulations usingReynolds-Averaged Navier-Stokes (RANS) equations or DES (Detached Eddy Simulation) for the single phaseflow and Lagrangian random walk eddy interaction models (EIMs) for the particulate phase will also beperformed and the results will be validated against the experimental data.

MMSI（麦克阿瑟Medical Sales Inc.，罗克顿，ON）开发了一种附加适配器，用于将能倍乐吸入器连接到市售面罩上，这将有助于某些患者（通常是老年人和儿童）吸入哮喘药物，这些人通常可能缺乏驱动和吸入之间的协调。（和面罩）对吸入性能的影响将在体外研究（间接使用理想的口-喉-气管复制品），并与单独使用能倍乐吸入器的有效性进行比较。沉积数值模拟使用雷诺平均Navier-Stokes（RANS）方程或DES（分离涡模拟）的单相流和拉格朗日随机行走涡相互作用模型（EIMs）的颗粒相也将被执行，结果将被验证对实验数据。