Quantification of the real-time near-infrared spectroscopic tissue oxygenation index using venous saturation in presence of cyclic muscular motion

近红外光谱（NIRS，也称为扩散光谱）是一种使用近红外光测量肌肉和大脑等身体组织中的血流和代谢的技术。近红外光谱是非侵入性的，人类看不见，也不电离（也就是说，它不像紫外线那样会致癌）。运动期间肌肉代谢的一个重要组成部分是耗氧量，科学家可以通过测量耗氧量来确定肌肉对运动的反应以及一个人是否从运动中受益。组织氧合指数（TOI）是衡量肌肉氧合的标准指标之一，但TOI的测定方法在不同的近红外光谱仪器中并不统一，这限制了TOI的广泛适用性和不同实验室及运动科学家所做评估的一致性。本研究的目的是建立一种新的方法来计算TOI的静脉饱和度存在的周期性运动。这将允许使用完善的和验证的技术inpulse血氧饱和度被应用到近红外光谱。静脉饱和度可以有创地测量，这允许使用金标准来校准该方法。这将提高NIRS仪器的一致性和准确性，这些仪器在许多环境中用于运动测试。

Near-infrared spectroscopy (NIRS, also known as diffuse optical spectroscopy) is a technique that usesnear-infrared light to measure blood flow and metabolism in body tissues like muscle and brain. NIRS isnon-invasive, invisible to humans, and non-ionizing (that is, it does not cause cancer, unlike ultraviolet light).An important component of muscle metabolism during exercise is oxygen consumption, which scientists canmeasure in order to determine how muscle is responding to exercise and whether a person is benefiting fromthe exercise. One of the standard measurements of muscle oxygen use is the tissue oxygenation index, or TOI.However, the methods used to determine TOI are not standardized across different NIRS instruments, and thislimits both its wide applicability and the consistency of the assessments done by various laboratories and sportscientists. The goal of this research is to establish a new method for calculating TOI using the venoussaturation in presence of cyclic motion. This will allow use of well established and validated techniques inpulse oximetry to be applied to NIRS. Venous saturation can be measured invasively which allows calibrationof the method using a gold standard. This will improve the consistency and accuracy of NIRS instruments thatare used for exercise testing in many settings.