Enabling the discovery and development of functional materials and technologies via confocal rheometry

点击翻译按钮获取中文摘要

Small scale technologies carry the potential for a revolutionary transformation of the discovery and development of new materials and therapeutics. A combination of the state-of-the-art microfluidic and nanofabrication research facilities at the Centre for Microfluidic Systems (CMS) in Chemistry and Biology at the University of Toronto, and an NSERC CREATE Training program in organ-on-a-chip engineering and entrepreneurship, is allowing us to train engineers and scientists with the integrated expertise required to bring these technologies into fruition. Our team of exceptional researchers has made significant advances towards the development of platforms for studying physical and mechanistic aspects of diseases, driving the discovery of therapeutics and drug delivery systems, developing new biomaterials, and studying live cell responses. Our research programs in these areas are being slowed down, however, because a majority of materials in our projects are fluid or gel like, but there is no instrument in CMS that can measure material rheology (the deformation and flow properties of materials). In this proposal, we request a rheometer that allows confocal microscopy along with rheological measurements. This hybrid instrument will allow us to prescribe accurate and controlled degrees of stresses on materials, while simultaneously imaging the changes in the three-dimensional, internal microstructure of the material. This powerful capability will address the characterization shortcomings mentioned above, enabling us to fulfil the potential of our research programs and facilitating their translation into commercially-available technologies. The CMS will house the confocal rheometer, and will provide the infrastructure and technical staff for support and maintenance. Training on the use of the instrument and the principles underlying its operation will be provided via short course directly offered by the principal investigator. When highly qualified personnel (HQP) involved in CMS and the CREATE program emerge from training, they will possess not only advanced technical knowledge but also entrepreneurial skills to translate technologies developed in our laboratories to successful spin-offs and jobs in Canada. Thus, our HQP will give Canadian industry a huge competitive edge.