Comparative Neurophysiology

比较神经生理学

• 批准号: 1000230954-2015
• 负责人: Pamenter, Matthew
• 金额: $ 7.29万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=643191
• 关键词: Comparative; Neurophysiology

Hypoxia is a central component of many diseases, including heart attack, ischemic stroke, and chronic lung diseases. Hypoxia is also common in nature and, not surprisingly, species have populated even the most hypoxic environments. Studying the cellular and systemic adaptations that enable animals to live in such niches offers unique insights into naturally evolved mechanisms that protect organisms against hypoxic or ischemic stresses. My research focus is the neurophysiological adaptations that protect hypoxia-tolerant brains. This work provides important insight into natural neuroprotective mechanisms against hypoxic stress, and may inform the development of novel treatments against hypoxic insults in brain.

缺氧是许多疾病的核心组成部分，包括心脏病发作、缺血性中风和慢性肺部疾病。缺氧在自然界中也很常见，毫不奇怪，即使是最缺氧的环境中也有物种居住。研究使动物能够生活在这样的生态位中的细胞和系统适应，为保护生物体免受缺氧或缺血应激的自然进化机制提供了独特的见解。我的研究重点是保护缺氧耐受大脑的神经生理学适应。这项工作提供了重要的洞察自然的神经保护机制，对缺氧应激，并可能告知新的治疗方法的发展，对缺氧损伤的大脑。