Comparative Neurophysiology

缺氧是许多疾病的中心组成部分，包括心脏病发作、缺血性中风和慢性肺部疾病。低氧在自然界中也很常见，毫不奇怪，即使在最低氧的环境中，物种也会出现。研究使动物能够生活在这样的利基环境中的细胞和系统适应能力，为自然进化的机制提供了独特的见解，这些机制保护生物免受缺氧或缺血应激的伤害。我的研究重点是保护耐缺氧大脑的神经生理适应。这项工作为了解针对低氧应激的自然神经保护机制提供了重要的见解，并可能为开发针对大脑中低氧损伤的新疗法提供信息。

Hypoxia is a central component of many diseases, including heart attack, ischemic stroke, and chronic lung diseases. Hypoxia is also common in nature and, not surprisingly, species have populated even the most hypoxic environments. Studying the cellular and systemic adaptations that enable animals to live in such niches offers unique insights into naturally evolved mechanisms that protect organisms against hypoxic or ischemic stresses. My research focus is the neurophysiological adaptations that protect hypoxia-tolerant brains. This work provides important insight into natural neuroprotective mechanisms against hypoxic stress, and may inform the development of novel treatments against hypoxic insults in brain.