Comparative Neurophysiology

比较神经生理学

• 批准号: 1000230954-2015
• 负责人: Pamenter, Matthew
• 金额: $ 8.74万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=693127
• 关键词: Comparative; Neurophysiology

Hypoxia is a central component of many diseases, including heart attack, ischemic stroke, and chronic lung diseases. Hypoxia is also common in nature and, not surprisingly, species have populated even the most hypoxic environments. Studying the cellular and systemic adaptations that enable animals to live in such niches offers unique insights into naturally evolved mechanisms that protect organisms against hypoxic or ischemic stresses. My research focus is the neurophysiological adaptations that protect hypoxia-tolerant brains. This work provides important insight into natural neuroprotective mechanisms against hypoxic stress, and may inform the development of novel treatments against hypoxic insults in brain.

缺氧是许多疾病的核心组成部分，包括心脏病发作，缺血性中风和慢性肺部疾病。缺氧在本质上也很常见，而且毫不奇怪，即使是最缺氧的环境，物种也已经填充了。研究使动物能够生活在这样的壁ches中的细胞和全身适应性提供了独特的见解，以保护有机体免受缺氧或缺血性胁迫的自然发展机制。我的研究重点是可保护耐透透大脑的神经生理适应。这项工作提供了针对低氧应激的自然神经保护机制的重要洞察力，并可能告知针对大脑中缺氧损伤的新型治疗方法。