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Targeted DNA demethylation based therapeutics.

Targeted DNA demethylation based therapeutics.
基于靶向 DNA 去甲基化的疗法。
批准号:
380053
负责人:
Szyf Moshe
金额:
$53.22万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2018
资助国家:
加拿大
项目状态:
已结题
起止时间:
2018-03-01 至 2023-03-01

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中文摘要
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英文摘要
Background. DNA methylation is an "epigenetic" chemical mark on DNA that punctuates and "programs" the "book of life". The Szyf lab pioneered the idea that different environmental experiences change DNA methylation and that changes in DNA methylation are
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Impact of Early life MetaBolic and psychosocial strEss on susceptibility to mental Disorders; from converging epigenetic signatures to novel targets for therapeutic intervention
  • 批准号:
    387208
  • 项目类别:
    Operating Grants
  • 资助金额:
    $5.46万
  • 财政年份:
    2018
  • 负责人:
    Szyf Moshe
  • 依托单位:
Mechanism of action of DNMT1 inhibitors; a pharmacoepigenomic analysis
  • 批准号:
    259684
  • 项目类别:
    Salary Programs
  • 资助金额:
    $24.04万
  • 财政年份:
    2012
  • 负责人:
    Szyf Moshe
  • 依托单位:
Mechanisms of action of DNA demethylation inhibition as a therapeutic strategy against liver cancer
  • 批准号:
    229020
  • 项目类别:
    Operating Grants
  • 资助金额:
    $16.39万
  • 财政年份:
    2011
  • 负责人:
    Szyf Moshe
  • 依托单位:
Mechanism of action of DNA methyltransferase (DNMT1) inhibitors and their therapeutic potential
  • 批准号:
    200288
  • 项目类别:
    Operating Grants
  • 资助金额:
    $71.62万
  • 财政年份:
    2010
  • 负责人:
    Szyf Moshe
  • 依托单位:
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