A Cutting-Edge Printer for Bio-Fabricating Tissue Scaffolds

用于生物制造组织支架的尖端打印机

• 批准号: RTI-2019-00663
• 负责人: Chen, Xiongbiao
• 金额: $ 10.93万
• 依托单位: University of Saskatchewan
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=647410
• 关键词: Cutting; Edge; Printer; Bio; Fabricating

Millions of people suffer from tissue/organ injuries, such as osteoarthritis and heart attacks. Tissue/organ transplantation is the gold standard to treat some of these types of injuries but is severely restricted as an option due to the limited availability of donor tissues/organs. Tissue engineering is an emerging field that aims to produce tissue/organ substitutes or tissue scaffolds that can grow with patients, ultimately providing a permanent solution by repairing/replacing what is damaged. Producing such tissue scaffolds, however, has proven to be a challenging task that has significantly limited progress towards clinical applications. An important barrier is the inability to fabricate scaffolds with structures and cell organizations that mimic those of native tissues/organs. In this application, we request a cutting-edge printer to enhance our capacity to fabricate tissue scaffolds with living cells based on a three-dimensional (3D) printing technique (that creates 3D objects by printing/depositing materials layer by layer). This enhanced capacity will enable us to develop novel scaffolds for tissue engineering applications, including myocardial infarction treatment, articular cartilage repair, tooth defect treatment, and stroke treatment, which are being actively pursued at the University of Saskatchewan. As such, the primary stakeholders of the research are the large number of Canadians who suffer from tissue/organ injuries as well as health researchers/practitioners/industry partners in related areas. This research will also involve the training of graduate students to meet the increasing demand for highly qualified personnel in the fields of tissue engineering and health care.

数以百万计的人遭受组织/器官损伤，如骨关节炎和心脏病发作。组织/器官移植是治疗其中一些类型损伤的黄金标准，但由于供体组织/器官的可获得性有限，作为一种选择受到严格限制。组织工程学是一个新兴的领域，旨在生产组织/器官替代品或组织支架，可以随着患者的生长而生长，最终通过修复/替换受损的东西来提供永久性的解决方案。然而，生产这种组织支架已被证明是一项具有挑战性的任务，大大限制了临床应用的进展。一个重要的障碍是无法制造出具有模仿天然组织/器官的结构和细胞组织的支架。在这项应用中，我们需要一台尖端打印机，以增强我们基于三维(3D)打印技术(通过逐层打印/沉积材料来创建3D对象)制造具有活细胞的组织支架的能力。这种增强的能力将使我们能够开发用于组织工程应用的新型支架，包括心肌梗死治疗、关节软骨修复、牙齿缺陷治疗和中风治疗，这些正在萨斯喀彻温省大学积极开展。因此，这项研究的主要利益攸关方是大量遭受组织/器官损伤的加拿大人以及相关领域的健康研究人员/从业者/行业合作伙伴。这项研究还将包括培养研究生，以满足组织工程和卫生保健领域对高素质人才日益增长的需求。