Design of new Asymmetric, Ion Pairing Catalysis and Reactions

新型不对称离子对催化和反应的设计

• 批准号: RGPIN-2015-04139
• 负责人: Davis, Rebecca
• 金额: $ 1.46万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=648749
• 关键词: Design; new; Asymmetric; Ion; Pairing

* * 0* 0* 1* 261* 1554* UofM* 23* 1* 1814* 14.0* * * * *** * Normal* 0* * * * * false* false* false* * EN-US* JA* X-NONE* * * * * * * * * * * * * * * * * * * * * * * * * ** * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * **** /* Style Definitions */*table.MsoNormalTable* {mso-style-name:"Table Normal";* mso-tstyle-rowband-size:0;* mso-tstyle-colband-size:0;* mso-style-noshow:yes;* mso-style-priority:99;* mso-style-parent:"";* mso-padding-alt:0cm 5.4pt 0cm 5.4pt;* mso-para-margin:0cm;* mso-para-margin-bottom:.0001pt;* mso-pagination:widow-orphan;* font-size:12.0pt;* font-family:Cambria;* mso-ascii-font-family:Cambria;* mso-ascii-theme-font:minor-latin;* mso-hansi-font-family:Cambria;* mso-hansi-theme-font:minor-latin;* mso-ansi-language:EN-US;}****The proposed research program*focuses on the development of asymmetric catalytic processes for the production*of chiral organic chemicals. Chiral compounds play an important role in*pharmaceutical and agrochemical industries. These molecules, which can exist as*mirror images (called enantiomers), are the building blocks of all life. It is*well established that the enantiomers of a compound can have vastly different*biological activities. It is a continuous challenge in organic chemistry to develop*robust and reliable asymmetric catalytic process that allow for the formation*of single enantiomers of chiral compounds. The field of Asymmetric, Ion Pairing*Catalysis represents an extremely promising and versatile approach for*generating a wide range of complex chiral molecules. While development*in this area of catalysis has been rapid, the rush to exploit the potential of*these methods has left a void between innovation and understanding. An in-depth*knowledge of the mechanisms of these catalysts is required to expand the arsenal*of reactions that can be performed with this asymmetric catalytic method.***The proposed*discovery research will provide fundamental insight into the mechanisms*of these asymmetric catalysts in generating single enantiomers of chiral*molecules. The proposed research will expand our arsenal of enantioselective*reactions, and lead the development of generally applicable, industrially*relevant catalytic methods*that will allow for the formation of previously unachievable complex chiral*molecules. Students*involved in this research program will develop skills in kinetic and computational*chemistry for exploring reactions mechanism and learn advanced synthesis and*characterization techniques that together will make them highly sought after*for their broad skill set.***

* * 0* 0* 1* 261* 1554* UofM* 23* 1* 1814* 14.0* * 正常 * 0 * false * false* * EN-US* JA* X-NONE* * * * * * * * * * * * * * * * * * * * * * * * * ** * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * ** * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * ** /* 样式定义 */*table.MsoNormalTable* {mso-style-name：“Table Normal”;* mso-tstyle-rowband-size：0;* mso-tstyle-colband-size：0;* mso-style-noshow：yes;* mso-style-priority：99;* mso-style-parent：“";* mso-padding-alt：0cm 5.4pt 0cm 5.4pt;* mso-para-margin-bottom：0cm;* mso-para-margin-bottom：.0001pt;* mso-pagination：widow-orphan;* font-size：12.0pt;* font-family：Cambria;* mso-assign-font-family：Cambria;* mso-assign-theme-font：minor-latin;* mso-hansi-font-family：坎布里亚;* mso-hansi-theme-font：minor-latin;* mso-ansi-language：EN-US;}* 拟议的研究计划 * 侧重于开发手性有机化学品生产 * 的不对称催化过程。手性化合物在制药和农用化学工业中发挥着重要作用。这些分子可以镜像存在（称为对映体），是所有生命的基石。众所周知，一种化合物的对映体可以具有截然不同的生物活性。发展稳定可靠的不对称催化方法，使手性化合物形成单一的对映体，是有机化学中一个持续的挑战。不对称离子对催化领域代表了一种非常有前途和通用的方法，用于 * 生成各种复杂的手性分子。虽然催化领域的发展非常迅速，但急于开发这些方法的潜力却在创新和理解之间留下了空白。需要深入了解这些催化剂的机制，以扩大可以用这种不对称催化方法进行的反应的武库。这项发现研究将为这些不对称催化剂生成手性分子的单一对映体的机理提供基本的见解。拟议中的研究将扩大我们的对映体选择性反应的武库，并领导普遍适用的，工业上相关的催化方法的发展，这将允许形成以前无法实现的复杂手性分子。参与该研究计划的学生将发展动力学和计算化学的技能，以探索反应机制，并学习先进的合成和表征技术，这些技术将使他们因其广泛的技能而备受追捧。