Design of new Asymmetric, Ion Pairing Catalysis and Reactions

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* * 0* 0* 1* 261* 1554* UofM* 23* 1* 1814* 14.0* * * * *** * Normal* 0* * * * * false* false* false* * EN-US* JA* X-NONE* * * * * * * * * * * * * * * * * * * * * * * * * ** * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * **** /* Style Definitions */*table.MsoNormalTable* {mso-style-name:"Table Normal";* mso-tstyle-rowband-size:0;* mso-tstyle-colband-size:0;* mso-style-noshow:yes;* mso-style-priority:99;* mso-style-parent:"";* mso-padding-alt:0cm 5.4pt 0cm 5.4pt;* mso-para-margin:0cm;* mso-para-margin-bottom:.0001pt;* mso-pagination:widow-orphan;* font-size:12.0pt;* font-family:Cambria;* mso-ascii-font-family:Cambria;* mso-ascii-theme-font:minor-latin;* mso-hansi-font-family:Cambria;* mso-hansi-theme-font:minor-latin;* mso-ansi-language:EN-US;}****The proposed research program*focuses on the development of asymmetric catalytic processes for the production*of chiral organic chemicals. Chiral compounds play an important role in*pharmaceutical and agrochemical industries. These molecules, which can exist as*mirror images (called enantiomers), are the building blocks of all life. It is*well established that the enantiomers of a compound can have vastly different*biological activities. It is a continuous challenge in organic chemistry to develop*robust and reliable asymmetric catalytic process that allow for the formation*of single enantiomers of chiral compounds. The field of Asymmetric, Ion Pairing*Catalysis represents an extremely promising and versatile approach for*generating a wide range of complex chiral molecules. While development*in this area of catalysis has been rapid, the rush to exploit the potential of*these methods has left a void between innovation and understanding. An in-depth*knowledge of the mechanisms of these catalysts is required to expand the arsenal*of reactions that can be performed with this asymmetric catalytic method.***The proposed*discovery research will provide fundamental insight into the mechanisms*of these asymmetric catalysts in generating single enantiomers of chiral*molecules. The proposed research will expand our arsenal of enantioselective*reactions, and lead the development of generally applicable, industrially*relevant catalytic methods*that will allow for the formation of previously unachievable complex chiral*molecules. Students*involved in this research program will develop skills in kinetic and computational*chemistry for exploring reactions mechanism and learn advanced synthesis and*characterization techniques that together will make them highly sought after*for their broad skill set.***