Soft Matter and Biological Physics at Surfaces

表面软物质和生物物理学

• 批准号: RGPIN-2014-06473
• 负责人: Dutcher, John
• 金额: $ 3.79万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=649826
• 关键词: Soft; Matter; Biological; Physics; Surfaces

My research program focuses on developing a fundamental understanding and predictive power for the physical properties of soft materials and biological systems, such as polymers, biopolymers and bacterial cells. The responsiveness and complexity of these materials and systems pose fascinating challenges to understand the underlying mechanisms of their complex behavior, and offer exciting opportunities to design and exploit these materials for new applications. Our work focuses on addressing questions such as: What are the mechanisms of action of novel antimicrobial compounds? How do bacteria move on surfaces? What is the nature of the binding sites of proteins with the underlying surface and with other proteins? For the polysaccharide nanoparticles discovered in my laboratory, what is the nature of their interaction with water? What are the structure and mechanical properties of naturally occurring biomaterials? To probe these questions in detail, we will use a wide range of state-of-the-art, surface-sensitive tools, unique sample geometries, and simplified, theoretical models that capture the essential physics and underlying mechanisms, within the context of a materials physics perspective. This work is necessarily multidisciplinary, spanning many disciplines such as physics, chemistry, microbiology, and food science, and local, national and international collaborations form an essential part of the research program. We hope that this will lead to an understanding of the underlying mechanisms for their behavior, and the discovery of new materials and strategies for designing and applying soft and biological materials in new applications.

我的研究计划侧重于发展对软材料和生物系统（如聚合物，生物聚合物和细菌细胞）的物理特性的基本理解和预测能力。这些材料和系统的响应性和复杂性对理解其复杂行为的潜在机制提出了迷人的挑战，并为设计和开发这些材料的新应用提供了令人兴奋的机会。我们的工作重点是解决以下问题：新型抗菌化合物的作用机制是什么？细菌如何在表面上移动？蛋白质与底层表面和其他蛋白质的结合位点的性质是什么？对于我实验室发现的多糖纳米颗粒，它们与水相互作用的性质是什么？天然生物材料的结构和机械性能是什么？为了详细探讨这些问题，我们将使用各种最先进的表面敏感工具，独特的样品几何形状，以及简化的理论模型，这些模型在材料物理学视角的背景下捕捉基本物理和基本机制。这项工作必然是多学科的，跨越许多学科，如物理学，化学，微生物学和食品科学，地方，国家和国际合作形成了研究计划的重要组成部分。我们希望这将有助于理解其行为的潜在机制，并发现新材料和新应用中设计和应用软材料和生物材料的策略。