Supramolecular and Medicinal Chemistry

超分子与药物化学

• 批准号: CRC-2015-00094
• 负责人: Hof, Fraser
• 金额: $ 7.29万
• 依托单位: University of Victoria
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=653713
• 关键词: Supramolecular; Medicinal; Chemistry

Life is controlled by molecules binding to each other. Their on/off states are controlled by subtle *structural changes, even the addition of only a single carbon atom ('methyl'). Dr. Hof has studied *how these mechanisms work, and has used those lessons to build an unprecedented set of *chemical tools for studying methylation pathways in life. These include the first inhibitors of a *protein that causes aggressive cancer, and a suite of tools that can sense, enrich, and disrupt the *actions of their targets. His work opens the door for the creation of new diagnostics, therapeutics, *and research reagents.

生命是由相互结合的分子控制的。它们的开/关状态是由细微的结构变化控制的，即使只增加了一个碳原子（“甲基”）。霍夫博士研究了这些机制是如何工作的，并利用这些经验建立了一套前所未有的化学工具来研究生命中的甲基化途径。这些包括导致侵袭性癌症的蛋白质的第一个抑制剂，以及一套可以感知，丰富和破坏其目标的工具。他的工作为创造新的诊断、治疗和研究试剂打开了大门。