Supramolecular and Medicinal Chemistry
Supramolecular and Medicinal Chemistry
批准号:
CRC-2015-00094
负责人:
Hof, Fraser
金额:
$7.29万
依托单位:
依托单位国家:
加拿大
项目类别:
Canada Research Chairs
财政年份:
2019
资助国家:
加拿大
项目状态:
已结题
起止时间:
2019-01-01 至 2020-12-31
中文摘要
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英文摘要
Life is controlled by molecules binding to each other. Their on/off states are controlled by subtle structural changes, even the addition of only a single carbon atom ('methyl'). Dr. Hof has studied how these mechanisms work, and has used those lessons to build an unprecedented set of chemical tools for studying methylation pathways in life. These include the first inhibitors of a protein that causes aggressive cancer, and a suite of tools that can sense, enrich, and disrupt the actions of their targets. His work opens the door for the creation of new diagnostics, therapeutics, and research reagents.
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Diversity-driven supramolecular and systems chemistry for biological applications
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批准号:RGPIN-2019-04806
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项目类别:Discovery Grants Program - Individual
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资助金额:$6.85万
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财政年份:2022
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负责人:Hof, Fraser
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依托单位:
Diversity-driven supramolecular and systems chemistry for biological applications
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批准号:RGPIN-2019-04806
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项目类别:Discovery Grants Program - Individual
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资助金额:$6.85万
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财政年份:2021
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负责人:Hof, Fraser
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依托单位:
Supramolecular And Medicinal Chemistry
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批准号:CRC-2015-00094
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项目类别:Canada Research Chairs
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资助金额:$1.82万
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财政年份:2021
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负责人:Hof, Fraser
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依托单位:
Supramolecular and Medicinal Chemistry
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批准号:CRC-2015-00094
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项目类别:Canada Research Chairs
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资助金额:$7.29万
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财政年份:2020
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负责人:Hof, Fraser
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依托单位:
Diversity-driven supramolecular and systems chemistry for biological applications
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批准号:RGPIN-2019-04806
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项目类别:Discovery Grants Program - Individual
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资助金额:$6.85万
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财政年份:2020
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负责人:Hof, Fraser
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依托单位:
MethylTrap : chemical affinity reagents for reliable and reproducible PTM-targeted proteomics - Phase 1 application
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批准号:544479-2019
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项目类别:Idea to Innovation
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资助金额:$9.11万
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财政年份:2019
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负责人:Hof, Fraser
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依托单位:
Automated Synthesizer for Diversity-Oriented Synthesis of Peptides and Peptoids
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批准号:RTI-2020-00062
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项目类别:Research Tools and Instruments
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资助金额:$10.9万
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财政年份:2019
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负责人:Hof, Fraser
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依托单位:
Diversity-driven supramolecular and systems chemistry for biological applications
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批准号:RGPIN-2019-04806
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项目类别:Discovery Grants Program - Individual
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资助金额:$6.85万
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财政年份:2019
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负责人:Hof, Fraser
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依托单位:
Supramolecular and Medicinal Chemistry
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批准号:CRC-2015-00094
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项目类别:Canada Research Chairs
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资助金额:$7.29万
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财政年份:2018
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负责人:Hof, Fraser
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依托单位:
Supramolecular agents for the binding of challenging protein surface motifs
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批准号:RGPIN-2014-05382
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项目类别:Discovery Grants Program - Individual
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资助金额:$4.95万
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财政年份:2018
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负责人:Hof, Fraser
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依托单位:
Supramolecular agents for the binding of challenging protein surface motifs
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批准号:RGPIN-2014-05382
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项目类别:Discovery Grants Program - Individual
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资助金额:$4.95万
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财政年份:2017
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负责人:Hof, Fraser
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依托单位:
Supramolecular and Medicinal Chemistry
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批准号:CRC-2015-00094
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项目类别:Canada Research Chairs
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资助金额:$7.29万
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财政年份:2017
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负责人:Hof, Fraser
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依托单位:
Identifying bioisosteres for cationic epigenetic motifs
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批准号:522177-2017
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项目类别:Engage Grants Program
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资助金额:$1.82万
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财政年份:2017
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负责人:Hof, Fraser
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依托单位:
Defining methylation signatures in yeast to improve commercial brewing
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批准号:500771-2016
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项目类别:Engage Grants Program
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资助金额:$1.82万
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财政年份:2016
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负责人:Hof, Fraser
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依托单位:
Supramolecular and Medicinal Chemistry
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批准号:CRC-2015-00094
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项目类别:Canada Research Chairs
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资助金额:$5.46万
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财政年份:2016
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负责人:Hof, Fraser
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依托单位:
Supramolecular agents for the binding of challenging protein surface motifs
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批准号:RGPIN-2014-05382
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项目类别:Discovery Grants Program - Individual
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资助金额:$4.95万
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财政年份:2016
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负责人:Hof, Fraser
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依托单位:
Bioorganic Chemistry
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批准号:1000224104-2010
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项目类别:Canada Research Chairs
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资助金额:$1.82万
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财政年份:2016
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负责人:Hof, Fraser
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依托单位:
Bioorganic Chemistry
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批准号:1224104-2010
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项目类别:Canada Research Chairs
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资助金额:$7.29万
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财政年份:2015
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负责人:Hof, Fraser
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依托单位:
Supramolecular agents for the binding of challenging protein surface motifs
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批准号:RGPIN-2014-05382
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项目类别:Discovery Grants Program - Individual
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资助金额:$4.95万
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财政年份:2015
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负责人:Hof, Fraser
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依托单位:
Multimode microplate reader and automated liquids handling system
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批准号:RTI-2016-00175
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项目类别:Research Tools and Instruments
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资助金额:$10.93万
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财政年份:2015
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负责人:Hof, Fraser
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依托单位:
海外基金