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Molecular basis to diet-dependent chromatin dependencies in prostate cancer

Molecular basis to diet-dependent chromatin dependencies in prostate cancer
前列腺癌饮食依赖性染色质依赖性的分子基础
批准号：
390144
负责人：
Labb David
金额：
$70.5万
依托单位：
Research Institute of the McGill University Health Centre
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2018
资助国家：
加拿大
项目状态：
已结题
起止时间：
2018-09-01 至 2023-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=390144&lang=en
关键词：
Cancer Biology Chromatin Crispr/Cas9 Ko Screens Diet Epigenetics Mouse Models Prostate Cancer

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英文摘要
Prostate cancer is the most prevalent cancer in men and a leading cause of cancer-related lethality. Consumption of saturated fat and obesity are linked with increased risk of prostate cancer progression and mortality but the underlying mechanisms of this
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Protein glycation acts as a substrate-dependent tumorigenic molecular switch in prostate cancer
Deconvoluting the role of diet and obesity in prostate cancer susceptibility through epigenomics
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