Investigation of the prebiotic properties of collagen hydrolysates

胶原蛋白水解物的益生元特性研究

• 批准号: 523219-2018
• 负责人: Kubow, Stan
• 金额: $ 0.91万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Engage Plus Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=656069
• 关键词: Investigation; prebiotic; properties; collagen; hydrolysates

Genacol Canada Corporation Inc. manufactures a bovine-sourced hydrolyzed collagen supplement (Genacol®**Original Formula), which has shown efficacy in two separate clinical trials for reducing joint pain. Following**digestion, hydrolyzed collagen yields bioavailable amino acids and peptides that can lead to the**health-promoting properties of the supplement. There is presently, however, no information as to whether the**peptides can survive digestive processes in order to exert prebiotic effects on probiotic bacteria as this could be**a mechanism for the joint health benefits of the product. A research challenge is that typically studies**examining prebiotic properties of food components use fermentors without consideration of the digestive**processes of the stomach and small intestine. In the present study, digestion of the stomach and small intestine**in a dynamic simulated gut digestion model will be used to generate peptides that can be tested for their**prebiotic properties with fermentors containing probiotic bacteria. This approach is the first step towards**identifying whether the Genacol collagen hydrolysate has prebiotic properties that can be promoted and**examined as a mechanism of action for the reduction of joint pain seen with this product.

Genacol Canada Corporation Inc.生产了牛的水解胶原蛋白补充剂（Genacol®**原始配方），该配方在两项单独的临床试验中显示了减少关节疼痛的效率。在**消化之后，水解的胶原蛋白会产生可生物利用的氨基酸和胡椒粉，从而导致补充剂的**促进健康的特性。但是，目前尚无关于**肽是否可以在消化过程中生存的信息，以便对益生菌细菌产生益生元的影响，因为这可能是对产品的共同健康益处的一种机制。一项研究挑战是，通常研究**研究食品成分的益生元特性使用发酵罐，而无需考虑压力和小肠的消化过程。在本研究中，将使用动态模拟肠道消化模型中应力和小肠**的消化来生成可以为其**益生元进行测试的辣椒。含有益生菌细菌的发酵罐的性质。这种方法是确定基因醇胶原蛋白水解物具有益生元特性的第一步，可以促进和**作为减少该产品关节疼痛的作用机理。