Investigation of the prebiotic properties of collagen hydrolysates

胶原蛋白水解物的益生元特性研究

• 批准号: 523219-2018
• 负责人: Kubow, Stan
• 金额: $ 0.91万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Engage Plus Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=656069
• 关键词: Investigation; prebiotic; properties; collagen; hydrolysates

Genacol Canada Corporation Inc. manufactures a bovine-sourced hydrolyzed collagen supplement (Genacol®**Original Formula), which has shown efficacy in two separate clinical trials for reducing joint pain. Following**digestion, hydrolyzed collagen yields bioavailable amino acids and peptides that can lead to the**health-promoting properties of the supplement. There is presently, however, no information as to whether the**peptides can survive digestive processes in order to exert prebiotic effects on probiotic bacteria as this could be**a mechanism for the joint health benefits of the product. A research challenge is that typically studies**examining prebiotic properties of food components use fermentors without consideration of the digestive**processes of the stomach and small intestine. In the present study, digestion of the stomach and small intestine**in a dynamic simulated gut digestion model will be used to generate peptides that can be tested for their**prebiotic properties with fermentors containing probiotic bacteria. This approach is the first step towards**identifying whether the Genacol collagen hydrolysate has prebiotic properties that can be promoted and**examined as a mechanism of action for the reduction of joint pain seen with this product.

Genacol加拿大公司生产一种牛源水解胶原蛋白补充剂（Genacol®**Original Formula），在两项独立的临床试验中显示出减轻关节疼痛的功效。经过消化后，水解的胶原蛋白会产生生物可利用的氨基酸和肽，这些氨基酸和肽可以使补充剂具有促进健康的特性。然而，目前还没有关于 ** 肽是否能在消化过程中存活以对益生菌发挥益生元作用的信息，因为这可能是该产品共同健康益处的机制。一个研究挑战是，典型的研究 ** 检查食物成分的益生元特性使用发酵罐，而不考虑胃和小肠的消化 ** 过程。在本研究中，在动态模拟肠道消化模型中消化胃和小肠 ** 将用于产生肽，这些肽可以用含有益生菌的发酵罐测试其 ** 益生元特性。这种方法是 ** 确定Genacol胶原蛋白水解产物是否具有可促进的益生元特性的第一步，并 ** 作为减少该产品所见关节疼痛的作用机制进行检查。