Investigation of the prebiotic properties of collagen hydrolysates

胶原蛋白水解物的益生元特性研究

• 批准号: 523219-2018
• 负责人: Kubow, Stan
• 金额: $ 0.91万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Engage Plus Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=656069
• 关键词: Investigation; prebiotic; properties; collagen; hydrolysates

Genacol Canada Corporation Inc. manufactures a bovine-sourced hydrolyzed collagen supplement (Genacol®**Original Formula), which has shown efficacy in two separate clinical trials for reducing joint pain. Following**digestion, hydrolyzed collagen yields bioavailable amino acids and peptides that can lead to the**health-promoting properties of the supplement. There is presently, however, no information as to whether the**peptides can survive digestive processes in order to exert prebiotic effects on probiotic bacteria as this could be**a mechanism for the joint health benefits of the product. A research challenge is that typically studies**examining prebiotic properties of food components use fermentors without consideration of the digestive**processes of the stomach and small intestine. In the present study, digestion of the stomach and small intestine**in a dynamic simulated gut digestion model will be used to generate peptides that can be tested for their**prebiotic properties with fermentors containing probiotic bacteria. This approach is the first step towards**identifying whether the Genacol collagen hydrolysate has prebiotic properties that can be promoted and**examined as a mechanism of action for the reduction of joint pain seen with this product.

Genacol Canada Corporation Inc. 生产一种牛源水解胶原蛋白补充剂（Genacol®** 原配方），两项独立的临床试验显示该补充剂可有效减轻关节疼痛。 **消化后，水解胶原蛋白产生生物可利用的氨基酸和肽，从而产生补充剂的**促进健康的特性。然而，目前还没有关于这些肽是否能够在消化过程中存活下来从而对益生菌发挥益生元作用的信息，因为这可能是该产品对关节健康有益的一种机制。研究面临的挑战是，通常研究**检查食品成分的益生元特性时使用发酵罐，而不考虑胃和小肠的消化**过程。在本研究中，动态模拟肠道消化模型中的胃和小肠消化将用于生成肽，这些肽可以用含有益生菌的发酵罐测试其**益生元特性。这种方法是**确定 Genacol 胶原蛋白水解物是否具有益生元特性的第一步，可以将其作为减轻该产品所见关节疼痛的作用机制来促进和**检查。