Investigation of the prebiotic properties of collagen hydrolysates
胶原蛋白水解物的益生元特性研究
基本信息
- 批准号:523219-2018
- 负责人:
- 金额:$ 0.91万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Engage Plus Grants Program
- 财政年份:2018
- 资助国家:加拿大
- 起止时间:2018-01-01 至 2019-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Genacol Canada Corporation Inc. manufactures a bovine-sourced hydrolyzed collagen supplement (Genacol®**Original Formula), which has shown efficacy in two separate clinical trials for reducing joint pain. Following**digestion, hydrolyzed collagen yields bioavailable amino acids and peptides that can lead to the**health-promoting properties of the supplement. There is presently, however, no information as to whether the**peptides can survive digestive processes in order to exert prebiotic effects on probiotic bacteria as this could be**a mechanism for the joint health benefits of the product. A research challenge is that typically studies**examining prebiotic properties of food components use fermentors without consideration of the digestive**processes of the stomach and small intestine. In the present study, digestion of the stomach and small intestine**in a dynamic simulated gut digestion model will be used to generate peptides that can be tested for their**prebiotic properties with fermentors containing probiotic bacteria. This approach is the first step towards**identifying whether the Genacol collagen hydrolysate has prebiotic properties that can be promoted and**examined as a mechanism of action for the reduction of joint pain seen with this product.
Genacol加拿大公司生产一种牛源水解胶原蛋白补充剂(Genacol®**Original Formula),在两项独立的临床试验中显示出减轻关节疼痛的功效。经过消化后,水解的胶原蛋白会产生生物可利用的氨基酸和肽,这些氨基酸和肽可以使补充剂具有促进健康的特性。然而,目前还没有关于 ** 肽是否能在消化过程中存活以对益生菌发挥益生元作用的信息,因为这可能是该产品共同健康益处的机制。一个研究挑战是,典型的研究 ** 检查食物成分的益生元特性使用发酵罐,而不考虑胃和小肠的消化 ** 过程。在本研究中,在动态模拟肠道消化模型中消化胃和小肠 ** 将用于产生肽,这些肽可以用含有益生菌的发酵罐测试其 ** 益生元特性。这种方法是 ** 确定Genacol胶原蛋白水解产物是否具有可促进的益生元特性的第一步,并 ** 作为减少该产品所见关节疼痛的作用机制进行检查。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Kubow, Stan其他文献
Isolation and in-vitro probiotic characterization of fructophilic lactic acid bacteria from Chinese fruits and flowers
- DOI:
10.1016/j.lwt.2019.01.038 - 发表时间:
2019-05-01 - 期刊:
- 影响因子:6
- 作者:
Sakandar, Hafiz Arbab;Kubow, Stan;Sadiq, Faizan Ahmed - 通讯作者:
Sadiq, Faizan Ahmed
Characterization and biological properties of peptides isolated from dried fermented cow milk products by RP-HPLC: Amino acid composition, antioxidant, antihypertensive, and antidiabetic properties
- DOI:
10.1111/1750-3841.15794 - 发表时间:
2021-06-19 - 期刊:
- 影响因子:3.9
- 作者:
Alu'datt, Muhammad H.;Al-u'datt, Doa'a G. F.;Kubow, Stan - 通讯作者:
Kubow, Stan
Probiotic Supplementation is Associated with Increased Antioxidant Capacity and Copper Chelation in C. difficile-Infected Fecal Water
- DOI:
10.3390/nu11092007 - 发表时间:
2019-09-01 - 期刊:
- 影响因子:5.9
- 作者:
Gaisawat, Mohd Baasir;Iskandar, Michele M.;Kubow, Stan - 通讯作者:
Kubow, Stan
Isoprostanes and isofurans as non-traditional risk factors for cardiovascular disease among Canadian Inuit
- DOI:
10.3109/10715762.2012.702900 - 发表时间:
2012-10-01 - 期刊:
- 影响因子:3.3
- 作者:
Alkazemi, Dalal;Egeland, Grace M.;Kubow, Stan - 通讯作者:
Kubow, Stan
Extract of Irish potatoes (Solanum tuberosum L.) decreases body weight gain and adiposity and improves glucose control in the mouse model of diet-induced obesity
- DOI:
10.1002/mnfr.201400013 - 发表时间:
2014-11-01 - 期刊:
- 影响因子:5.2
- 作者:
Kubow, Stan;Hobson, Luc;Agellon, Luis B. - 通讯作者:
Agellon, Luis B.
Kubow, Stan的其他文献
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{{ truncateString('Kubow, Stan', 18)}}的其他基金
Investigation of the protective effects of probiotics and polyphenols on polychlorinated biphenyl-induced inflammation and oxidative stress: impact of biotransformation
益生菌和多酚对多氯联苯诱导的炎症和氧化应激的保护作用的研究:生物转化的影响
- 批准号:
RGPIN-2020-04901 - 财政年份:2022
- 资助金额:
$ 0.91万 - 项目类别:
Discovery Grants Program - Individual
Investigation of the protective effects of probiotics and polyphenols on polychlorinated biphenyl-induced inflammation and oxidative stress: impact of biotransformation
益生菌和多酚对多氯联苯诱导的炎症和氧化应激的保护作用的研究:生物转化的影响
- 批准号:
RGPIN-2020-04901 - 财政年份:2021
- 资助金额:
$ 0.91万 - 项目类别:
Discovery Grants Program - Individual
Identification of bioactive peptides from digestion of collagen hydrolysates
从胶原蛋白水解物的消化中鉴定生物活性肽
- 批准号:
535744-2018 - 财政年份:2021
- 资助金额:
$ 0.91万 - 项目类别:
Collaborative Research and Development Grants
Investigation of the protective effects of probiotics and polyphenols on polychlorinated biphenyl-induced inflammation and oxidative stress: impact of biotransformation
益生菌和多酚对多氯联苯诱导的炎症和氧化应激的保护作用的研究:生物转化的影响
- 批准号:
RGPIN-2020-04901 - 财政年份:2020
- 资助金额:
$ 0.91万 - 项目类别:
Discovery Grants Program - Individual
Bioactives generated from in vitro gut microbial metabolism of cannabinoid extract containing oil: effects on the microbiome, anti-inflammatory and anticancer effects
含油大麻素提取物的体外肠道微生物代谢产生的生物活性:对微生物组的影响、抗炎和抗癌作用
- 批准号:
542004-2019 - 财政年份:2020
- 资助金额:
$ 0.91万 - 项目类别:
Collaborative Research and Development Grants
Identification of bioactive peptides from digestion of collagen hydrolysates
从胶原蛋白水解物的消化中鉴定生物活性肽
- 批准号:
535744-2018 - 财政年份:2020
- 资助金额:
$ 0.91万 - 项目类别:
Collaborative Research and Development Grants
Identification of bioactive peptides from digestion of collagen hydrolysates
从胶原蛋白水解物的消化中鉴定生物活性肽
- 批准号:
535744-2018 - 财政年份:2019
- 资助金额:
$ 0.91万 - 项目类别:
Collaborative Research and Development Grants
Bioactives generated from in vitro gut microbial metabolism of cannabinoid extract containing oil: effects on the microbiome, anti-inflammatory and anticancer effects
含油大麻素提取物的体外肠道微生物代谢产生的生物活性:对微生物组的影响、抗炎和抗癌作用
- 批准号:
542004-2019 - 财政年份:2019
- 资助金额:
$ 0.91万 - 项目类别:
Collaborative Research and Development Grants
Investigation of the protective effects of polyphenols on polychlorinated biphenyl-induced inflammation and oxidative stress: impact of biotransformation
多酚对多氯联苯诱导的炎症和氧化应激的保护作用的研究:生物转化的影响
- 批准号:
RGPIN-2014-06291 - 财政年份:2018
- 资助金额:
$ 0.91万 - 项目类别:
Discovery Grants Program - Individual
Investigation of the protective effects of polyphenols on polychlorinated biphenyl-induced inflammation and oxidative stress: impact of biotransformation
多酚对多氯联苯诱导的炎症和氧化应激的保护作用的研究:生物转化的影响
- 批准号:
RGPIN-2014-06291 - 财政年份:2017
- 资助金额:
$ 0.91万 - 项目类别:
Discovery Grants Program - Individual
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