Investigation of the prebiotic properties of collagen hydrolysates

胶原蛋白水解物的益生元特性研究

• 批准号: 523219-2018
• 负责人: Kubow, Stan
• 金额: $ 0.91万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Engage Plus Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=656069
• 关键词: Investigation; prebiotic; properties; collagen; hydrolysates

Genacol Canada Corporation Inc. manufactures a bovine-sourced hydrolyzed collagen supplement (Genacol®**Original Formula), which has shown efficacy in two separate clinical trials for reducing joint pain. Following**digestion, hydrolyzed collagen yields bioavailable amino acids and peptides that can lead to the**health-promoting properties of the supplement. There is presently, however, no information as to whether the**peptides can survive digestive processes in order to exert prebiotic effects on probiotic bacteria as this could be**a mechanism for the joint health benefits of the product. A research challenge is that typically studies**examining prebiotic properties of food components use fermentors without consideration of the digestive**processes of the stomach and small intestine. In the present study, digestion of the stomach and small intestine**in a dynamic simulated gut digestion model will be used to generate peptides that can be tested for their**prebiotic properties with fermentors containing probiotic bacteria. This approach is the first step towards**identifying whether the Genacol collagen hydrolysate has prebiotic properties that can be promoted and**examined as a mechanism of action for the reduction of joint pain seen with this product.

Genacol Canada Corporation Inc.生产一种牛来源的水解胶原蛋白补充剂(Genacol®**原始配方)，该补充剂已在两个单独的临床试验中显示出缓解关节疼痛的效果。经过消化，水解胶原蛋白产生生物可利用的氨基酸和多肽，这可以导致补充剂的**促进健康的特性。然而，目前还没有关于这些多肽是否能在消化过程中存活下来以对益生菌施加益生菌效应的信息，因为这可能是该产品联合健康益处的**机制。一个研究挑战是，研究食品成分的益生菌特性的典型研究使用发酵器，而不考虑胃和小肠的消化过程。在本研究中，在动态模拟肠道消化模型中，胃和小肠的消化将被用来产生可以用含有益生菌的发酵器测试其**益生特性的多肽。这种方法是**确定Genacol胶原蛋白水解物是否具有可推广的益生菌特性的第一步，并**作为该产品所见的减少关节疼痛的作用机制进行**检验。