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Bioactives generated from in vitro gut microbial metabolism of cannabinoid extract containing oil: effects on the microbiome, anti-inflammatory and anticancer effects

含油大麻素提取物的体外肠道微生物代谢产生的生物活性：对微生物组的影响、抗炎和抗癌作用

基本信息

批准号：
542004-2019
负责人：
Kubow, Stan
金额：
$ 6.8万
依托单位：
McGill University
依托单位国家：
加拿大
项目类别：
Collaborative Research and Development Grants
财政年份：
2020
资助国家：
加拿大
起止时间：
2020-01-01 至 2021-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=699230
关键词：
Bioactives generated vitro gut microbial

项目摘要

Cannabinoids, particularly cannabidiol (CBD) have garnered considerable interest in terms of their anti-inflammatory and anticancer potential. However, most research to date has been based on in vitro and animal studies. In vitro studies conducted so far have not taken into consideration the role of digestion and the human gut microbiome in the biotransformation of cannabinoids, a crucial step that occurs prior to cannabinoids and their metabolites reaching their target tissues. The microbiome is known to play a central role in mediating or modulating the effects of ingested compounds and is heavily involved in local and systemic effects, including with respect to inflammation. Animal studies can provide useful insight but are limited in their translation to humans partly due to inherent differences between rodent and human gut microbiota. This study will address these limitations by examining the anti-inflammatory and anticancer effects of cannabinoids and their metabolites in intestinal cells, after they have been subjected to a simulated human gut digestion model involving microbial biotransformation. In addition, the study will explore the effects of ingested cannabinoids on gut microbial profiles, as well as characterize the cannabinoid and other metabolites produced by the microbiota in response to administration of a cannabinoid-rich oil.

大麻类化合物，特别是大麻二酚(CBD)因其抗炎和抗癌的潜力而引起了人们的极大兴趣。然而，到目前为止，大多数研究都是基于体外和动物研究。迄今为止进行的体外研究没有考虑到消化和人体肠道微生物群在大麻素生物转化中的作用，这是在大麻素及其代谢物到达目标组织之前发生的关键步骤。已知微生物组在调节或调节摄入化合物的影响方面发挥核心作用，并严重参与局部和全身影响，包括与炎症有关的影响。动物研究可以提供有用的见解，但在将其翻译到人类方面受到限制，部分原因是啮齿动物和人类肠道微生物群之间的固有差异。这项研究将通过检测大麻素及其代谢物在肠道细胞中的抗炎和抗癌作用来解决这些局限性，这些大麻素及其代谢物在经历了涉及微生物生物转化的模拟人类肠道消化模型后。此外，这项研究还将探讨摄入的大麻素对肠道微生物谱的影响，以及描述微生物群在服用富含大麻素的油时产生的大麻素和其他代谢物的特征。