Bioactives generated from in vitro gut microbial metabolism of cannabinoid extract containing oil: effects on the microbiome, anti-inflammatory and anticancer effects

含油大麻素提取物的体外肠道微生物代谢产生的生物活性:对微生物组的影响、抗炎和抗癌作用

基本信息

  • 批准号:
    542004-2019
  • 负责人:
  • 金额:
    $ 6.8万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Collaborative Research and Development Grants
  • 财政年份:
    2020
  • 资助国家:
    加拿大
  • 起止时间:
    2020-01-01 至 2021-12-31
  • 项目状态:
    已结题

项目摘要

Cannabinoids, particularly cannabidiol (CBD) have garnered considerable interest in terms of their anti-inflammatory and anticancer potential. However, most research to date has been based on in vitro and animal studies. In vitro studies conducted so far have not taken into consideration the role of digestion and the human gut microbiome in the biotransformation of cannabinoids, a crucial step that occurs prior to cannabinoids and their metabolites reaching their target tissues. The microbiome is known to play a central role in mediating or modulating the effects of ingested compounds and is heavily involved in local and systemic effects, including with respect to inflammation. Animal studies can provide useful insight but are limited in their translation to humans partly due to inherent differences between rodent and human gut microbiota. This study will address these limitations by examining the anti-inflammatory and anticancer effects of cannabinoids and their metabolites in intestinal cells, after they have been subjected to a simulated human gut digestion model involving microbial biotransformation. In addition, the study will explore the effects of ingested cannabinoids on gut microbial profiles, as well as characterize the cannabinoid and other metabolites produced by the microbiota in response to administration of a cannabinoid-rich oil.
大麻类化合物,特别是大麻二酚(CBD)因其抗炎和抗癌的潜力而引起了人们的极大兴趣。然而,到目前为止,大多数研究都是基于体外和动物研究。迄今为止进行的体外研究没有考虑到消化和人体肠道微生物群在大麻素生物转化中的作用,这是在大麻素及其代谢物到达目标组织之前发生的关键步骤。已知微生物组在调节或调节摄入化合物的影响方面发挥核心作用,并严重参与局部和全身影响,包括与炎症有关的影响。动物研究可以提供有用的见解,但在将其翻译到人类方面受到限制,部分原因是啮齿动物和人类肠道微生物群之间的固有差异。这项研究将通过检测大麻素及其代谢物在肠道细胞中的抗炎和抗癌作用来解决这些局限性,这些大麻素及其代谢物在经历了涉及微生物生物转化的模拟人类肠道消化模型后。此外,这项研究还将探讨摄入的大麻素对肠道微生物谱的影响,以及描述微生物群在服用富含大麻素的油时产生的大麻素和其他代谢物的特征。

项目成果

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Kubow, Stan其他文献

Isolation and in-vitro probiotic characterization of fructophilic lactic acid bacteria from Chinese fruits and flowers
  • DOI:
    10.1016/j.lwt.2019.01.038
  • 发表时间:
    2019-05-01
  • 期刊:
  • 影响因子:
    6
  • 作者:
    Sakandar, Hafiz Arbab;Kubow, Stan;Sadiq, Faizan Ahmed
  • 通讯作者:
    Sadiq, Faizan Ahmed
Characterization and biological properties of peptides isolated from dried fermented cow milk products by RP-HPLC: Amino acid composition, antioxidant, antihypertensive, and antidiabetic properties
  • DOI:
    10.1111/1750-3841.15794
  • 发表时间:
    2021-06-19
  • 期刊:
  • 影响因子:
    3.9
  • 作者:
    Alu'datt, Muhammad H.;Al-u'datt, Doa'a G. F.;Kubow, Stan
  • 通讯作者:
    Kubow, Stan
Probiotic Supplementation is Associated with Increased Antioxidant Capacity and Copper Chelation in C. difficile-Infected Fecal Water
  • DOI:
    10.3390/nu11092007
  • 发表时间:
    2019-09-01
  • 期刊:
  • 影响因子:
    5.9
  • 作者:
    Gaisawat, Mohd Baasir;Iskandar, Michele M.;Kubow, Stan
  • 通讯作者:
    Kubow, Stan
Isoprostanes and isofurans as non-traditional risk factors for cardiovascular disease among Canadian Inuit
  • DOI:
    10.3109/10715762.2012.702900
  • 发表时间:
    2012-10-01
  • 期刊:
  • 影响因子:
    3.3
  • 作者:
    Alkazemi, Dalal;Egeland, Grace M.;Kubow, Stan
  • 通讯作者:
    Kubow, Stan
Extract of Irish potatoes (Solanum tuberosum L.) decreases body weight gain and adiposity and improves glucose control in the mouse model of diet-induced obesity
  • DOI:
    10.1002/mnfr.201400013
  • 发表时间:
    2014-11-01
  • 期刊:
  • 影响因子:
    5.2
  • 作者:
    Kubow, Stan;Hobson, Luc;Agellon, Luis B.
  • 通讯作者:
    Agellon, Luis B.

Kubow, Stan的其他文献

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{{ truncateString('Kubow, Stan', 18)}}的其他基金

Investigation of the protective effects of probiotics and polyphenols on polychlorinated biphenyl-induced inflammation and oxidative stress: impact of biotransformation
益生菌和多酚对多氯联苯诱导的炎症和氧化应激的保护作用的研究:生物转化的影响
  • 批准号:
    RGPIN-2020-04901
  • 财政年份:
    2022
  • 资助金额:
    $ 6.8万
  • 项目类别:
    Discovery Grants Program - Individual
Investigation of the protective effects of probiotics and polyphenols on polychlorinated biphenyl-induced inflammation and oxidative stress: impact of biotransformation
益生菌和多酚对多氯联苯诱导的炎症和氧化应激的保护作用的研究:生物转化的影响
  • 批准号:
    RGPIN-2020-04901
  • 财政年份:
    2021
  • 资助金额:
    $ 6.8万
  • 项目类别:
    Discovery Grants Program - Individual
Identification of bioactive peptides from digestion of collagen hydrolysates
从胶原蛋白水解物的消化中鉴定生物活性肽
  • 批准号:
    535744-2018
  • 财政年份:
    2021
  • 资助金额:
    $ 6.8万
  • 项目类别:
    Collaborative Research and Development Grants
Investigation of the protective effects of probiotics and polyphenols on polychlorinated biphenyl-induced inflammation and oxidative stress: impact of biotransformation
益生菌和多酚对多氯联苯诱导的炎症和氧化应激的保护作用的研究:生物转化的影响
  • 批准号:
    RGPIN-2020-04901
  • 财政年份:
    2020
  • 资助金额:
    $ 6.8万
  • 项目类别:
    Discovery Grants Program - Individual
Identification of bioactive peptides from digestion of collagen hydrolysates
从胶原蛋白水解物的消化中鉴定生物活性肽
  • 批准号:
    535744-2018
  • 财政年份:
    2020
  • 资助金额:
    $ 6.8万
  • 项目类别:
    Collaborative Research and Development Grants
Identification of bioactive peptides from digestion of collagen hydrolysates
从胶原蛋白水解物的消化中鉴定生物活性肽
  • 批准号:
    535744-2018
  • 财政年份:
    2019
  • 资助金额:
    $ 6.8万
  • 项目类别:
    Collaborative Research and Development Grants
Bioactives generated from in vitro gut microbial metabolism of cannabinoid extract containing oil: effects on the microbiome, anti-inflammatory and anticancer effects
含油大麻素提取物的体外肠道微生物代谢产生的生物活性:对微生物组的影响、抗炎和抗癌作用
  • 批准号:
    542004-2019
  • 财政年份:
    2019
  • 资助金额:
    $ 6.8万
  • 项目类别:
    Collaborative Research and Development Grants
Investigation of the prebiotic properties of collagen hydrolysates
胶原蛋白水解物的益生元特性研究
  • 批准号:
    523219-2018
  • 财政年份:
    2018
  • 资助金额:
    $ 6.8万
  • 项目类别:
    Engage Plus Grants Program
Investigation of the protective effects of polyphenols on polychlorinated biphenyl-induced inflammation and oxidative stress: impact of biotransformation
多酚对多氯联苯诱导的炎症和氧化应激的保护作用的研究:生物转化的影响
  • 批准号:
    RGPIN-2014-06291
  • 财政年份:
    2018
  • 资助金额:
    $ 6.8万
  • 项目类别:
    Discovery Grants Program - Individual
Investigation of the protective effects of polyphenols on polychlorinated biphenyl-induced inflammation and oxidative stress: impact of biotransformation
多酚对多氯联苯诱导的炎症和氧化应激的保护作用的研究:生物转化的影响
  • 批准号:
    RGPIN-2014-06291
  • 财政年份:
    2017
  • 资助金额:
    $ 6.8万
  • 项目类别:
    Discovery Grants Program - Individual

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UVB 辐射产生的微泡颗粒作为光敏效应器
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UVB 辐射产生的微泡颗粒作为光敏效应器
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Bioactives generated from in vitro gut microbial metabolism of cannabinoid extract containing oil: effects on the microbiome, anti-inflammatory and anticancer effects
含油大麻素提取物的体外肠道微生物代谢产生的生物活性:对微生物组的影响、抗炎和抗癌作用
  • 批准号:
    542004-2019
  • 财政年份:
    2019
  • 资助金额:
    $ 6.8万
  • 项目类别:
    Collaborative Research and Development Grants
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项目 3:微生物群在心脏代谢疾病中产生芳基硫酸盐和次级胆汁酸
  • 批准号:
    10206257
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    2019
  • 资助金额:
    $ 6.8万
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Cellular mechanisms of hippocampal network neuroplasticity generated by brain stimulation
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  • 批准号:
    10025187
  • 财政年份:
    2019
  • 资助金额:
    $ 6.8万
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